[HTML][HTML] Omicron variant (B. 1.1. 529) and its sublineages: What do we know so far amid the emergence of recombinant variants of SARS-CoV-2?

M Dhawan, ARA Saied, S Mitra, FA Alhumaydhi… - Biomedicine & …, 2022 - Elsevier
Since the start of the COVID-19 pandemic, numerous variants of SARS-CoV-2 have been
reported worldwide. The advent of variants of concern (VOCs) raises severe concerns amid …

Individual genetic variability mainly of Proinflammatory cytokines, cytokine receptors, and toll‐like receptors dictates pathophysiology of COVID‐19 disease

MK Vakil, Y Mansoori, GRL Al‐Awsi… - Journal of Medical …, 2022 - Wiley Online Library
Innate and acquired immunity responses are crucial for viral infection elimination. However,
genetic variations in coding genes may exacerbate the inflammation or initiate devastating …

Heterologous immunization with inactivated vaccine followed by mRNA-booster elicits strong immunity against SARS-CoV-2 Omicron variant

F Zuo, H Abolhassani, L Du, A Piralla… - Nature …, 2022 - nature.com
The recent emergence of the Omicron variant has raised concerns on vaccine efficacy and
the urgent need to study more efficient vaccination strategies. Here we observed that an …

Interim analysis from a phase 2 randomized trial of EuCorVac-19: a recombinant protein SARS-CoV-2 RBD nanoliposome vaccine

JF Lovell, YO Baik, SK Choi, C Lee, JY Lee, K Miura… - BMC medicine, 2022 - Springer
Background Numerous vaccine strategies are being advanced to control SARS-CoV-2, the
cause of the COVID-19 pandemic. EuCorVac-19 (ECV19) is a recombinant protein …

SARS-CoV-2 Spike Proteins and Cell–Cell Communication Induce P-Selectin and Markers of Endothelial Injury, NETosis, and Inflammation in Human Lung …

B Bhargavan, GD Kanmogne - International journal of molecular sciences, 2023 - mdpi.com
COVID-19 progression often involves severe lung injury, inflammation, coagulopathy, and
leukocyte infiltration into pulmonary tissues. The pathogenesis of these complications is …

Some common deleterious mutations are shared in SARS-CoV-2 genomes from deceased COVID-19 patients across continents

MA Islam, AA Marzan, MS Arman, S Shahi, TI Sakif… - Scientific Reports, 2023 - nature.com
The identification of deleterious mutations in different variants of SARS-CoV-2 and their
roles in the morbidity of COVID-19 patients has yet to be thoroughly investigated. To unravel …

In vitro efficacy of antivirals and monoclonal antibodies against SARS-CoV-2 omicron lineages XBB. 1.9. 1, XBB. 1.9. 3, XBB. 1.5, XBB. 1.16, XBB. 2.4, BQ. 1.1. 45, CH …

AA Pochtovyi, DD Kustova, AE Siniavin, IV Dolzhikova… - Vaccines, 2023 - mdpi.com
The spread of COVID-19 continues, expressed by periodic wave-like increases in morbidity
and mortality. The reason for the periodic increases in morbidity is the emergence and …

[HTML][HTML] SARS-CoV-2 and COVID-19: a narrative review

AD Blann, R Heitmar - British Journal of Biomedical …, 2022 - frontierspartnerships.org
The World Health Organisation has reported that the viral disease known as COVID-19,
caused by SARS-CoV-2, is the leading cause of death by a single infectious agent. This …

[HTML][HTML] Review of concerned SARS-CoV-2 variants like Alpha (B. 1.1. 7), Beta (B. 1.351), Gamma (P. 1), Delta (B. 1.617. 2), and Omicron (B. 1.1. 529), as well as …

S Zahmatkesh, M Sillanpaa, Y Rezakhani… - Journal of Hazardous …, 2022 - Elsevier
The coronavirus known as COVID-19, which causes pandemics, is causing a global
epidemic at a critical stage today. Furthermore, novel mutations in the SARS-CoV-2 spike …

SARS-CoV-2 spike proteins and cell–cell communication inhibits TFPI and induces thrombogenic factors in human lung microvascular endothelial cells and …

B Bhargavan, GD Kanmogne - International journal of molecular sciences, 2022 - mdpi.com
In SARS-CoV-2-infected humans, disease progression is often associated with acute
respiratory distress syndrome involving severe lung injury, coagulopathy, and thrombosis of …