Network approach in liquidomics landscape

D Santini, A Botticelli, A Galvano, M Iuliani… - Journal of Experimental …, 2023 - Springer
Tissue-based biopsy is the present main tool to explore the molecular landscape of cancer,
but it also has many limits to be frequently executed, being too invasive with the risk of side …

[HTML][HTML] Genomic approaches to cancer and minimal residual disease detection using circulating tumor DNA

NP Semenkovich, JJ Szymanski… - … for immunotherapy of …, 2023 - ncbi.nlm.nih.gov
Liquid biopsies using cell-free circulating tumor DNA (ctDNA) are being used frequently in
both research and clinical settings. ctDNA can be used to identify actionable mutations to …

A shared neoantigen vaccine combined with immune checkpoint blockade for advanced metastatic solid tumors: phase 1 trial interim results

AR Rappaport, C Kyi, M Lane, MG Hart, ML Johnson… - Nature Medicine, 2024 - nature.com
Therapeutic vaccines that elicit cytotoxic T cell responses targeting tumor-specific
neoantigens hold promise for providing long-term clinical benefit to patients with cancer …

Neoadjuvant nivolumab or nivolumab plus LAG-3 inhibitor relatlimab in resectable esophageal/gastroesophageal junction cancer: a phase Ib trial and ctDNA …

RJ Kelly, BV Landon, AH Zaidi, D Singh… - Nature medicine, 2024 - nature.com
Gastroesophageal cancer dynamics and drivers of clinical responses with immune
checkpoint inhibitors (ICI) remain poorly understood. Potential synergistic activity of dual …

Dynamics of sequence and structural cell-free DNA landscapes in small-cell lung cancer

L Sivapalan, WT Iams, Z Belcaid, SC Scott… - Clinical Cancer …, 2023 - AACR
Purpose: Patients with small-cell lung cancer (SCLC) have an exceptionally poor prognosis,
calling for improved real-time noninvasive biomarkers of therapeutic response. Experimental …

Durvalumab±Tremelimumab+ Platinum-etoposide in extensive-stage small cell lung cancer (CASPIAN): outcomes by PD-L1 expression and tissue tumor mutational …

L Paz-Ares, MC Garassino, Y Chen, N Reinmuth… - Clinical Cancer …, 2024 - AACR
Purpose: In the CASPIAN trial, first-line durvalumab plus platinum-etoposide (EP)
significantly improved overall survival (OS) versus EP alone in extensive-stage small cell …

Elucidating the heterogeneity of immunotherapy response and immune-related toxicities by longitudinal ctDNA and immune cell compartment tracking in lung cancer

JC Murray, L Sivapalan, K Hummelink, A Balan… - Clinical Cancer …, 2024 - AACR
Purpose: Although immunotherapy is the mainstay of therapy for advanced non–small cell
lung cancer (NSCLC), robust biomarkers of clinical response are lacking. The heterogeneity …

Research on liquid biopsy for cancer: A bibliometric analysis

S Jiang, Y Liu, Y Xu, X Sang, X Lu - Heliyon, 2023 - cell.com
Background: In recent years, liquid biopsy has shown great potential for improving cancer
diagnosis and treatment. This study aimed to explore the trends and prospects in liquid …

Beyond blood: Advancing the frontiers of liquid biopsy in oncology and personalized medicine

Y Bao, D Zhang, H Guo, W Ma - Cancer Science, 2024 - Wiley Online Library
Liquid biopsy is emerging as a pivotal tool in precision oncology, offering a noninvasive and
comprehensive approach to cancer diagnostics and management. By harnessing biofluids …

[HTML][HTML] Liquid biopsy: Cell-free DNA based analysis in breast cancer

K Venetis, G Cursano, C Pescia, M D'Ercole… - The Journal of Liquid …, 2023 - Elsevier
Breast cancer management has witnessed significant advancements, especially in the
diagnosis and treatment response monitoring through the implementation of imaging …