Network medicine for Alzheimer's disease and traditional Chinese medicine

JT Jarrell, L Gao, DS Cohen, X Huang - Molecules, 2018 - mdpi.com
Alzheimer's Disease (AD) is a neurodegenerative condition that currently has no known
cure. The principles of the expanding field of network medicine (NM) have recently been …

Comprehensive gene and pathway analysis of cervical cancer progression

Y Yi, Y Fang, K Wu, Y Liu, W Zhang - Oncology letters, 2020 - spandidos-publications.com
Cervical Cancer is one of the leading causes of cancer‑associated mortality in women. The
present study aimed to identify key genes and pathways involved in cervical cancer (CC) …

Computational systems biology approaches for Parkinson's disease

E Glaab - Cell and tissue research, 2018 - Springer
Parkinson's disease (PD) is a prime example of a complex and heterogeneous disorder,
characterized by multifaceted and varied motor-and non-motor symptoms and different …

[HTML][HTML] The adverse outcome pathway (AOP) of estrogen interference effect induced by triphenyl phosphate (TPP): Integrated multi-omics and molecular dynamics …

R Guan, N Li, W Wang, W Liu, X Li, C Zhao - … and Environmental Safety, 2022 - Elsevier
Triphenyl phosphate (TPP) has been detected with increasing frequency in various biota
and environmental media, and it has been confirmed that G protein-coupled estrogen …

Using advanced bioinformatics tools to identify novel therapeutic candidates for age-related macular degeneration

U Nadeem, B Xie, EF Xie, M D'Souza… - … Vision Science & …, 2022 - tvst.arvojournals.org
Purpose: Age-related macular degeneration (AMD) is the most common cause of aging-
related blindness in the developing world. Although medications can slow progressive wet …

MENDA: a comprehensive curated resource of metabolic characterization in depression

J Pu, Y Yu, Y Liu, L Tian, S Gui, X Zhong… - Briefings in …, 2020 - academic.oup.com
Depression is a seriously disabling psychiatric disorder with a significant burden of disease.
Metabolic abnormalities have been widely reported in depressed patients and animal …

Huangqin decoction exerts beneficial effects on rotenone-induced rat model of Parkinson's disease by improving mitochondrial dysfunction and alleviating metabolic …

L Gao, M Cao, G Du, X Qin - Frontiers in aging neuroscience, 2022 - frontiersin.org
Parkinson's disease (PD) is a common neurodegenerative disease, and the pathogenesis of
PD is closely related to mitochondrial dysfunction. Previous studies have indicated that …

Combined analysis of DNA methylation and gene expression profiles of osteosarcoma identified several prognosis signatures

W Tian, Y Li, J Zhang, J Li, J Gao - Gene, 2018 - Elsevier
Osteosarcoma (OS) is a common primary malignancy in children and adolescents with
relative high survival rate after chemotherapy. While, the toxicity of chemotherapy and …

Benzo [b] fluoranthene induces male reproductive toxicity and apoptosis via Akt-Mdm2-p53 signaling axis in mouse Leydig cells: Integrating computational toxicology …

C Shi, F Han, X Jiang, Z Zhang, Y Li, J Wang… - Food and Chemical …, 2023 - Elsevier
This study aims to explore the male reproductive toxicity of Benzo [b] fluoranthene (BbF) and
related mechanisms. The results of computational toxicology analysis indicated male …

Transcriptomic analysis reveals key genes related to antioxidant mechanisms of Hylocereus undatus quality improvement by trypsin during storage

X Li, X Liu, Y Yin, H Yu, M Zhang, H Jing, Y Ma… - Food & function, 2019 - pubs.rsc.org
It has been revealed in our previous studies that trypsin scavenges superoxide anions. In
the current study, the mechanisms of storage quality improvement by trypsin were evaluated …