[HTML][HTML] Human disease models in drug development
A Loewa, JJ Feng, S Hedtrich - Nature reviews bioengineering, 2023 - nature.com
Biomedical research is undergoing a paradigm shift towards approaches centred on human
disease models owing to the notoriously high failure rates of the current drug development …
disease models owing to the notoriously high failure rates of the current drug development …
[HTML][HTML] Cognitive impact of COVID-19: looking beyond the short term
COVID-19 is primarily a respiratory disease but up to two thirds of hospitalised patients show
evidence of central nervous system (CNS) damage, predominantly ischaemic, in some …
evidence of central nervous system (CNS) damage, predominantly ischaemic, in some …
[HTML][HTML] IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro
Interferon-induced transmembrane proteins (IFITMs 1, 2 and 3) can restrict viral pathogens,
but pro-and anti-viral activities have been reported for coronaviruses. Here, we show that …
but pro-and anti-viral activities have been reported for coronaviruses. Here, we show that …
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): a systemic infection
A Synowiec, A Szczepański… - Clinical microbiology …, 2021 - Am Soc Microbiol
To date, seven identified coronaviruses (CoVs) have been found to infect humans; of these,
three highly pathogenic variants have emerged in the 21st century. The newest member of …
three highly pathogenic variants have emerged in the 21st century. The newest member of …
[HTML][HTML] The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2
S Krasemann, U Haferkamp, S Pfefferle, MS Woo… - Stem cell reports, 2022 - cell.com
Neurological complications are common in COVID-19. Although SARS-CoV-2 has been
detected in patients' brain tissues, its entry routes and resulting consequences are not well …
detected in patients' brain tissues, its entry routes and resulting consequences are not well …
[HTML][HTML] Neurological complications and infection mechanism of SARS-COV-2
D Wan, T Du, W Hong, L Chen, H Que, S Lu… - Signal Transduction and …, 2021 - nature.com
Abstract Currently, SARS-CoV-2 has caused a global pandemic and threatened many lives.
Although SARS-CoV-2 mainly causes respiratory diseases, growing data indicate that SARS …
Although SARS-CoV-2 mainly causes respiratory diseases, growing data indicate that SARS …
[HTML][HTML] ApoE-isoform-dependent SARS-CoV-2 neurotropism and cellular response
ApoE4, a strong genetic risk factor for Alzheimer disease, has been associated with
increased risk for severe COVID-19. However, it is unclear whether ApoE4 alters COVID-19 …
increased risk for severe COVID-19. However, it is unclear whether ApoE4 alters COVID-19 …
Morphological, cellular, and molecular basis of brain infection in COVID-19 patients
Although increasing evidence confirms neuropsychiatric manifestations associated mainly
with severe COVID-19 infection, long-term neuropsychiatric dysfunction (recently …
with severe COVID-19 infection, long-term neuropsychiatric dysfunction (recently …
[HTML][HTML] The role of Neuropilin-1 in COVID-19
BS Mayi, JA Leibowitz, AT Woods, KA Ammon… - PLoS …, 2021 - journals.plos.org
Neuropilin-1 (NRP-1), a member of a family of signaling proteins, was shown to serve as an
entry factor and potentiate SARS Coronavirus 2 (SARS-CoV-2) infectivity in vitro. This cell …
entry factor and potentiate SARS Coronavirus 2 (SARS-CoV-2) infectivity in vitro. This cell …
[HTML][HTML] A human three-dimensional neural-perivascular 'assembloid'promotes astrocytic development and enables modeling of SARS-CoV-2 neuropathology
Clinical evidence suggests the central nervous system is frequently impacted by SARS-CoV-
2 infection, either directly or indirectly, although the mechanisms are unclear. Pericytes are …
2 infection, either directly or indirectly, although the mechanisms are unclear. Pericytes are …