Interactions between SARS-CoV-2 N-protein and α-synuclein accelerate amyloid formation

SA Semerdzhiev, MAA Fakhree… - ACS chemical …, 2021 - ACS Publications
First cases that point at a correlation between SARS-CoV-2 infections and the development
of Parkinson's disease (PD) have been reported. Currently, it is unclear if there is also a …

Application of 3D bioprinting in the prevention and the therapy for human diseases

HG Yi, H Kim, J Kwon, YJ Choi, J Jang… - Signal Transduction and …, 2021 - nature.com
Rapid development of vaccines and therapeutics is necessary to tackle the emergence of
new pathogens and infectious diseases. To speed up the drug discovery process, the …

SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation

G Xu, Y Li, S Zhang, H Peng, Y Wang, D Li, T Jin, Z He… - Cell research, 2021 - nature.com
Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), is the ongoing global pandemic that poses …

SARS-CoV-2 infection and viral fusogens cause neuronal and glial fusion that compromises neuronal activity

R Martínez-Mármol, R Giordano-Santini, E Kaulich… - Science …, 2023 - science.org
Numerous viruses use specialized surface molecules called fusogens to enter host cells.
Many of these viruses, including the severe acute respiratory syndrome coronavirus 2 …

Post COVID-19 condition in children and adolescents: an emerging problem

J Izquierdo-Pujol, S Moron-Lopez, J Dalmau… - Frontiers in …, 2022 - frontiersin.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection became a
pandemic in 2020 and by March 2022 had caused more than 479 million infections and 6 …

The COVID-19 pandemic and Alzheimer's disease: mutual risks and mechanisms

F Chen, Y Chen, Y Wang, Q Ke, L Cui - Translational neurodegeneration, 2022 - Springer
Abstract Coronavirus disease 2019 (COVID-19), which is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is a life-threatening disease, especially …

Revealing tissue-specific SARS-CoV-2 infection and host responses using human stem cell-derived lung and cerebral organoids

SK Tiwari, S Wang, D Smith, AF Carlin, TM Rana - Stem Cell Reports, 2021 - cell.com
COVID-19 is a transmissible respiratory disease caused by a novel coronavirus, SARS-CoV-
2, and has become a global health emergency. There is an urgent need for robust and …

Tropism of SARS-CoV-2 for human cortical astrocytes

MG Andrews, T Mukhtar, UC Eze… - Proceedings of the …, 2022 - National Acad Sciences
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) readily infects a variety
of cell types impacting the function of vital organ systems, with particularly severe impact on …

Inflammation at the crossroads of COVID-19, cognitive deficits and depression

NML e Silva, FGQ Barros-Aragão, FG De Felice… - …, 2022 - Elsevier
Acute neurological alterations have been associated with SARS-CoV-2 infection.
Additionally, it is becoming clear that coronavirus disease 2019 (COVID-19) survivors may …

Full protection from SARS-CoV-2 brain infection and damage in susceptible transgenic mice conferred by MVA-CoV2-S vaccine candidate

J Villadiego, J García-Arriaza, R Ramírez-Lorca… - Nature …, 2023 - nature.com
Vaccines against SARS-CoV-2 have been shown to be safe and effective but their protective
efficacy against infection in the brain is yet unclear. Here, in the susceptible transgenic K18 …