Human 3D brain organoids: steering the demolecularization of brain and neurological diseases

YK Adlakha - Cell Death Discovery, 2023 - nature.com
Understanding of human brain development, dysfunction and neurological diseases has
remained limited and challenging due to inability to recapitulate human brain-specific …

[HTML][HTML] Neurotropic viruses, astrocytes, and COVID-19

P Tavčar, M Potokar, M Kolenc, M Korva… - Frontiers in cellular …, 2021 - frontiersin.org
At the end of 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was
discovered in China, causing a new coronavirus disease, termed COVID-19 by the WHO on …

[HTML][HTML] An airway organoid-based screen identifies a role for the HIF1α-glycolysis axis in SARS-CoV-2 infection

X Duan, X Tang, MS Nair, T Zhang, Y Qiu, W Zhang… - Cell reports, 2021 - cell.com
It is urgent to develop disease models to dissect mechanisms regulating severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Here, we derive airway …

Organoid and microfluidics-based platforms for drug screening in COVID-19

R Ramezankhani, R Solhi, YC Chai, M Vosough… - Drug discovery today, 2022 - Elsevier
Highlights•Modelling platforms facilitate identification of therapeutic and prophylactic
approaches in COVID-19.•Genome based strategies and computational platforms have …

SARS-CoV-2 invades cognitive centers of the brain and induces Alzheimer's-like neuropathology

WB Shen, M Elahi, J Logue, P Yang, L Baracco… - BioRxiv, 2022 - biorxiv.org
The neurotropism of SARS-CoV-2 and the phenotypes of infected neurons are still in
debate. Long COVID manifests with “brain diseases” and the cause of these brain …

Single-nucleus transcriptome analysis of human brain immune response in patients with severe COVID-19

JF Fullard, HC Lee, G Voloudakis, S Suo, B Javidfar… - Genome medicine, 2021 - Springer
Abstract Background Coronavirus disease 2019 (COVID-19), caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has been associated with …

Persistence of symptoms 15 months since COVID-19 diagnosis: prevalence, risk factors and residual work ability

D Sansone, A Tassinari, R Valentinotti, D Kontogiannis… - Life, 2022 - mdpi.com
Background: A proportion of patients' ailments may last after recovering from acute COVID-
19, with episodic and systemic symptoms of unclear etiology potentially involving different …

Haemorrhage of human foetal cortex associated with SARS-CoV-2 infection

M Massimo, C Barelli, C Moreno, C Collesi… - Brain, 2023 - academic.oup.com
Maternal viral infection and immune response are known to increase the risk of altered
development of the foetal brain. Given the ongoing global pandemic of coronavirus disease …

A review on SARS-CoV-2-induced neuroinflammation, neurodevelopmental complications, and recent updates on the vaccine development

M Karnik, NM Beeraka, CA Uthaiah, SM Nataraj… - Molecular …, 2021 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is a devastating viral infection caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The incidence and …

Amyloid precursor protein facilitates SARS-CoV-2 virus entry into cells and enhances amyloid-β-associated pathology in APP/PS1 mouse model of Alzheimer's …

J Chen, J Chen, Z Lei, F Zhang, LH Zeng, X Wu… - Translational …, 2023 - nature.com
Although there are indications of a trend towards less severe acute respiratory symptoms
and a decline in overall lethality from the novel Coronavirus Disease 2019 (COVID-19) …