SARS-CoV-2 infection of human neurons is TMPRSS2 independent, requires endosomal cell entry, and can be blocked by inhibitors of host phosphoinositol-5 kinase

P Kettunen, A Lesnikova, N Räsänen, R Ojha… - Journal of …, 2023 - Am Soc Microbiol
ABSTRACT 2019 coronavirus disease (COVID-19) is a disease caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). In addition to respiratory illness, COVID …

[HTML][HTML] C-Phycocyanin-derived phycocyanobilin as a potential nutraceutical approach for major neurodegenerative disorders and COVID-19-induced damage to the …

G Pentón-Rol, J Marín-Prida… - Current …, 2021 - ncbi.nlm.nih.gov
The edible cyanobacterium Spirulina platensis and its chief biliprotein C-Phycocyanin have
shown protective activity in animal models of diverse human health diseases, often reflecting …

Brain fog: A narrative review of the most common mysterious cognitive disorder in COVID-19

M Aghajani Mir - Molecular Neurobiology, 2023 - Springer
It has been more than three years since COVID-19 impacted the lives of millions of people,
many of whom suffer from long-term effects known as long-haulers. Notwithstanding …

[HTML][HTML] Endocytosis and transcytosis of SARS-CoV-2 across the intestinal epithelium and other tissue barriers

E Knyazev, S Nersisyan, A Tonevitsky - Frontiers in immunology, 2021 - frontiersin.org
Since 2003, the world has been confronted with three new betacoronaviruses that cause
human respiratory infections: SARS-CoV, which causes severe acute respiratory syndrome …

Cellular mechanisms underlying neurological/neuropsychiatric manifestations of COVID‐19

B Bodnar, K Patel, W Ho, JJ Luo… - Journal of Medical …, 2021 - Wiley Online Library
Patients with severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection
manifest mainly respiratory symptoms. However, clinical observations frequently identified …

3D printed human organoids: High throughput system for drug screening and testing in current COVID‐19 pandemic

A Parihar, V Pandita, R Khan - Biotechnology and …, 2022 - Wiley Online Library
In the current pandemic, scenario the world is facing a huge shortage of effective drugs and
other prophylactic medicine to treat patients which created havoc in several countries with …

[HTML][HTML] Brain disease network analysis to elucidate the neurological manifestations of COVID-19

K Prasad, SY AlOmar, SAM Alqahtani, MZ Malik… - Molecular …, 2021 - Springer
Although COVID-19 largely causes respiratory complications, it can also lead to various
extrapulmonary manifestations resulting in higher mortality and these comorbidities are …

Severe acute respiratory syndrome coronavirus 2 infection leads to Tau pathological signature in neurons

C Di Primio, P Quaranta, M Mignanelli, G Siano… - PNAS …, 2023 - academic.oup.com
COVID-19 has represented an issue for global health since its outbreak in March 2020. It is
now evident that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

[HTML][HTML] Research progress, challenges, and breakthroughs of organoids as disease models

Y Huang, Z Huang, Z Tang, Y Chen… - Frontiers in Cell and …, 2021 - frontiersin.org
Traditional cell lines and xenograft models have been widely recognized and used in
research. As a new research model, organoids have made significant progress and …

[HTML][HTML] Human brain organoids as models for central nervous system viral infection

JA Depla, LA Mulder, RV de Sá, M Wartel, A Sridhar… - Viruses, 2022 - mdpi.com
Pathogenesis of viral infections of the central nervous system (CNS) is poorly understood,
and this is partly due to the limitations of currently used preclinical models. Brain organoid …