SARS-CoV-2 and neurodegenerative diseases: What we know and what we don't

P Lingor, AF Demleitner, AW Wolff… - Journal of Neural …, 2022 - Springer
Infection of the CNS with the SARS-CoV-2 can occur via different routes and results in para-
or post-infectious manifestations with a variety of neurological symptoms. In patients with …

Brain organoids are new tool for drug screening of neurological diseases

JQ Zhou, LH Zeng, CT Li, DH He… - Neural Regeneration …, 2023 - journals.lww.com
At the level of in vitro drug screening, the development of a phenotypic analysis system with
high-content screening at the core provides a strong platform to support high-throughput …

SARS-CoV-2 poorly replicates in cells of the human blood-brain barrier without associated deleterious effects

O Constant, J Barthelemy, K Bollore, E Tuaillon… - Frontiers in …, 2021 - frontiersin.org
Various neurological symptoms have been associated to severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection including headache, fever, anosmia, ageusia, but …

Infection of brain organoids and 2D cortical neurons with SARS-CoV-2 pseudovirus

SA Yi, KH Nam, J Yun, D Gim, D Joe, YH Kim, HJ Kim… - Viruses, 2020 - mdpi.com
Since the global outbreak of SARS-CoV-2 (COVID-19), infections of diverse human organs
along with multiple symptoms continue to be reported. However, the susceptibility of the …

Can SARS-CoV-2 infection lead to neurodegeneration and Parkinson's disease?

L Krey, MK Huber, GU Höglinger, F Wegner - Brain Sciences, 2021 - mdpi.com
The SARS-CoV-2 pandemic has affected the daily life of the worldwide population since
2020. Links between the newly discovered viral infection and the pathogenesis of …

[HTML][HTML] SARS-CoV-2 infects and replicates in photoreceptor and retinal ganglion cells of human retinal organoids

Y Menuchin-Lasowski, A Schreiber, A Lecanda… - Stem cell reports, 2022 - cell.com
Several studies have pointed to retinal involvement in COVID-19, yet many questions
remain regarding the ability of SARS-CoV-2 to infect and replicate in retinal cells and its …

SARS-CoV-2 infects primary neurons from human ACE2 expressing mice and upregulates genes involved in the inflammatory and necroptotic pathways

HA Rothan, P Kumari, S Stone, JP Natekar, K Arora… - Pathogens, 2022 - mdpi.com
Transgenic mice expressing human angiotensin-converting enzyme 2 under the cytokeratin
18 promoter (K18-hACE2) have been extensively used to investigate the pathogenesis and …

Advances in 3D culture systems for therapeutic discovery and development in brain cancer

J Wanigasekara, PJ Cullen, P Bourke, B Tiwari… - Drug Discovery …, 2023 - Elsevier
Highlights•Existing models for drug discovery and development against glioblastoma
multiforme (GBM) have limitations.•We review advances in 3D systems that promise more …

Delta (B1. 617.2) variant of SARS-CoV-2 induces severe neurotropic patterns in K18-hACE2 mice

JH Yang, MS Yang, DM Kim, B Kim, D Tark… - Scientific Reports, 2023 - nature.com
A highly contagious virus, severe acute respiratory syndrome coronavirus 2, caused the
coronavirus disease 19 (COVID-19) pandemic (SARS-CoV-2). SARS-CoV-2 genetic …

Emerging neurological and psychobiological aspects of COVID-19 infection

L Tancheva, MC Petralia, S Miteva, S Dragomanova… - Brain sciences, 2020 - mdpi.com
The SARS-CoV-2 virus, first reported in December 2019 in China, is the causative agent of
the current COVID-19 pandemic that, at the time of writing (1 November 2020) has infected …