Activator protein-1 (AP-1) was first identified as a transcriptional factor that binds to an
essential cis-ele-ment of the human metallothionein lla (hMTIla) promoter [1]. AP-1 is …

Study of GSK-3 had an inauspicious beginning rooted in intermediary metabolism. However,
owing to the fortuitous convergence of several disparate areas of biology, the enzyme now …

The activity of c-Jun is regulated by phosphorylation. Various stimuli including transforming
oncogenes and UV light, induce phosphorylation of serines 63 and 73 in the amino-terminal …

THE proto-oncogene c-jun is a component of the AP-1 transcription factor family involved in
the mediation of nuclear events elicited by extracellular stimuli1–3. The c-jun protein is …

Several different oncogenes and growth factors promote G 1 phase progression. Cyclin D1,
the regulatory subunit of several cyclin-dependent kinases, is required for, and capable of …

The role of the ubiquitin-dependent proteolysis system in c-Jun breakdown was
investigated. Using in vitro experiments and a novel in vivo assay that utilizes molecularly …

We present evidence that the glucocorticold receptor (OR) and transcrlptlon factor Jun/AP-1
can reciprocally repress one another's transcrlptlonal activation by a novel mechanism that …

In resting human epithelial and fibroblastic cells, c-Jun is phosphorylated on serine and
threonine at five sites, three of which are phosphorylated in vitro by glycogen synthase …

PLATELET activation by the coagulation protease thrombin is central to arterial thrombosis,
a major cause of morbidity and mortality. We recently isolated a complementary DNA …

Binding activity for nuclear factor kappa B (NFkappaB) consensus probes was studied in
nuclear extracts from peripheral blood mononuclear cells of 15 septic patients (10 surviving …