Alzheimer's disease: a brief history of immunotherapies targeting amyloid β

ACS Vogt, GT Jennings, MO Mohsen, M Vogel… - International journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is the most common form of dementia and may contribute to 60–
70% of cases. Worldwide, around 50 million people suffer from dementia and the prediction …

Inflammatory processes in alzheimer's disease—pathomechanism, diagnosis and treatment: a review

B Twarowski, M Herbet - International journal of molecular sciences, 2023 - mdpi.com
Alzheimer's disease is one of the most commonly diagnosed cases of senile dementia in the
world. It is an incurable process, most often leading to death. This disease is multifactorial …

Alzheimer's disease: treatment strategies and their limitations

E Passeri, K Elkhoury, M Morsink, K Broersen… - International journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) is the most frequent case of neurodegenerative disease and is
becoming a major public health problem all over the world. Many therapeutic strategies …

Donanemab for Alzheimer's disease: a systematic review of clinical trials

A Rashad, A Rasool, M Shaheryar, A Sarfraz, Z Sarfraz… - Healthcare, 2022 - mdpi.com
Amyloid-β (Aβ) plaques and aggregated tau are two core mechanisms that contribute to the
clinical deterioration of Alzheimer's disease (AD). Recently, targeted-Aβ plaque reduction …

The Amyloid-beta clearance: from molecular targets to glial and neural cells

W Cai, T Wu, N Chen - Biomolecules, 2023 - mdpi.com
The deposition of amyloid-beta (Aβ) plaques in the brain is one of the primary pathological
characteristics of Alzheimer's disease (AD). It can take place 20–30 years before the onset of …

New pathways identify novel drug targets for the prevention and treatment of Alzheimer's disease

B Penke, M Szűcs, F Bogár - International Journal of Molecular Sciences, 2023 - mdpi.com
Alzheimer's disease (AD) is an incurable, progressive neurodegenerative disorder. AD is a
complex and multifactorial disease that is responsible for 60–80% of dementia cases. Aging …

The challenges of anti-tau therapeutics in Alzheimer disease

F Panza, M Lozupone - Nature Reviews Neurology, 2022 - nature.com
A phase II trial of the tau antibody semorinemab indicates that it has no clinical benefit in the
earliest stages of Alzheimer disease. The repeated finding that antibody-mediated …

Dietary protection against cognitive impairment, Neuroinflammation and oxidative stress in Alzheimer's disease animal models of lipopolysaccharide-induced …

D Decandia, F Gelfo, E Landolfo, F Balsamo… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is a rapidly growing epidemic with a heavy social and economic
burden. Evidence suggests that systemic inflammation, dysregulation of the immune …

Recent advancement in therapeutic strategies for Alzheimer's disease: insights from clinical trials

T Khan, R Waseem, M Shahid, J Ansari… - Ageing Research …, 2023 - Elsevier
Alzheimer's disease (AD) is the most prevalent form of dementia, characterized by the
presence of plaques of amyloid beta and Tau proteins. There is currently no permanent cure …

Targeting aging and age-related diseases with vaccines

R Wu, F Sun, W Zhang, J Ren, GH Liu - Nature Aging, 2024 - nature.com
Aging is a major risk factor for numerous chronic diseases. Vaccination offers a promising
strategy to combat these age-related diseases by targeting specific antigens and inducing …