Ageing and atherosclerosis: vascular intrinsic and extrinsic factors and potential role of IL-6

DJ Tyrrell, DR Goldstein - Nature Reviews Cardiology, 2021 - nature.com
The number of old people is rising worldwide, and advancing age is a major risk factor for
atherosclerotic cardiovascular disease. However, the mechanisms underlying this …

Immunosenescence and human vaccine immune responses

SN Crooke, IG Ovsyannikova, GA Poland… - Immunity & …, 2019 - Springer
The age-related dysregulation and decline of the immune system—collectively termed
“immunosenescence”—has been generally associated with an increased susceptibility to …

[HTML][HTML] Debunking the myth of exercise-induced immune suppression: redefining the impact of exercise on immunological health across the lifespan

JP Campbell, JE Turner - Frontiers in immunology, 2018 - frontiersin.org
Epidemiological evidence indicates that regular physical activity and/or frequent structured
exercise reduces the incidence of many chronic diseases in older age, including …

Efficacy, immunogenicity, and safety of a plant-derived, quadrivalent, virus-like particle influenza vaccine in adults (18–64 years) and older adults (≥ 65 years): two …

BJ Ward, A Makarkov, A Séguin, S Pillet, S Trépanier… - The Lancet, 2020 - thelancet.com
Background Seasonal influenza remains a substantial public health threat despite the
availability of egg-derived and other vaccines. Plant-based manufacturing might address …

[HTML][HTML] Vaccination in the elderly: the challenge of immune changes with aging

A Ciabattini, C Nardini, F Santoro, P Garagnani… - Seminars in …, 2018 - Elsevier
The unprecedented increase of life expectancy challenges society to protect the elderly from
morbidity and mortality making vaccination a crucial mean to safeguard this population …

The antioxidant, immunomodulatory, and anti-inflammatory activities of Spirulina: an overview

Q Wu, L Liu, A Miron, B Klímová, D Wan, K Kuča - Archives of toxicology, 2016 - Springer
Spirulina is a species of filamentous cyanobacteria that has long been used as a food
supplement. In particular, Spirulina platensis and Spirulina maxima are the most important …

Age and immunity: what is “immunosenescence”?

G Pawelec - Experimental gerontology, 2018 - Elsevier
As is apparent from the many contributions to this Special Issue of the Journal, the impact of
age on immunity is nefarious, with all manner of dysregulated responses attributed to …

Integrative physiology of pneumonia

LJ Quinton, AJ Walkey, JP Mizgerd - Physiological reviews, 2018 - journals.physiology.org
Pneumonia is a type of acute lower respiratory infection that is common and severe. The
outcome of lower respiratory infection is determined by the degrees to which immunity is …

Human T cell immunosenescence and inflammation in aging

A Bektas, SH Schurman, R Sen… - Journal of leukocyte …, 2017 - Wiley Online Library
The aging process is driven by a finite number of inter‐related mechanisms that ultimately
lead to the emergence of characteristic phenotypes, including increased susceptibility to …

The regulation of inflammation by innate and adaptive lymphocytes

DA Cronkite, TM Strutt - Journal of immunology research, 2018 - Wiley Online Library
Inflammation plays an essential role in the control of pathogens and in shaping the ensuing
adaptive immune responses. Traditionally, innate immunity has been described as a rapid …