The dominant hypothesis of Alzheimer's disease (AD) aetiology, the neuropathological
guidelines for diagnosing AD and the majority of high-profile therapeutic efforts, in both …

The serine hydrolase butyrylcholinesterase (BChE), like the related enzyme
acetylcholinesterase (AChE), co-regulates metabolism of the neurotransmitter acetylcholine …

The pathology-based classification of Alzheimer's disease (AD) and other
neurodegenerative diseases is a work in progress that is important for both clinicians and …

Hippocampal sclerosis of aging (HS-Aging) is a causative factor in a large proportion of
elderly dementia cases. The current definition of HS-Aging rests on pathologic criteria …

Late-onset Alzheimer's disease (AD) is the most prevalent cause of dementia among older
adults, yet more than a century of research has not determined why this disease develops …

Hippocampal sclerosis of ageing is a prevalent brain disease that afflicts older persons and
has been linked with cerebrovascular pathology. Arteriolosclerosis is a subtype of …

Abstract See Gordon (doi: 10.1093/brain/awy052) for a scientific commentary on this article.
Predicting underlying pathology based on clinical presentation has historically proven …

Many Alzheimer's disease (AD) patients suffer from cerebrovascular abnormalities such as
altered cerebral blood flow and cerebral microinfarcts. Recently, fibrinogen has been …

Alzheimer's disease (AD) is a complex, multicausal disorder involving several
spatiotemporal scales and scientific domains. While many studies focus on specific parts of …

Brain glucose hypometabolism has been observed in Alzheimer's disease (AD) patients,
and is detected with 18F radiolabelled glucose, using positron emission tomography. A …