Many biological circuits comprise sets of protein variants that interact with one another in a
many-to-many, or promiscuous, fashion. These architectures can provide powerful …

Signal integration is central to a causal understanding of appropriately scaled inflammatory
responses. Here, we discuss recent progress in our understanding of the stimulus–response …

In multicellular organisms, cell types must be produced and maintained in appropriate
proportions. One way this is achieved is through committed progenitor cells or extrinsic …

The Notch signaling pathway uses families of ligands and receptors to transmit signals to
nearby cells. These components are expressed in diverse combinations in different cell …

Signaling pathways feature multiple interacting ligand and receptor variants, which are
thought to act in a combinatorial manner to elicit different cellular responses. Transcriptome …

Many biological signaling pathways employ proteins that competitively dimerize in diverse
combinations. These dimerization networks can perform biochemical computations, in which …

Hematopoietic stem and progenitor cells (HSPCs) rely on intercellular signaling to maintain
and adjust their production of blood and immune cells. This process occurs in the semi …

Abstract The 13th Federation of American Societies for Experimental Biology (FASEB)
Summer Research Conference,“TGF-β superfamily signaling in development and disease” …