[HTML][HTML] Stress, epigenetics, and aging: unraveling the intricate crosstalk
Aging, as a complex process involving multiple cellular and molecular pathways, is known to
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …
The central role of DNA damage in immunosenescence
L Kell, AK Simon, G Alsaleh, LS Cox - Frontiers in Aging, 2023 - frontiersin.org
Ageing is the biggest risk factor for the development of multiple chronic diseases as well as
increased infection susceptibility and severity of diseases such as influenza and COVID-19 …
increased infection susceptibility and severity of diseases such as influenza and COVID-19 …
Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology
Aging is a major risk factor for neurodegenerative diseases, and coronavirus disease 2019
(COVID-19) is linked to severe neurological manifestations. Senescent cells contribute to …
(COVID-19) is linked to severe neurological manifestations. Senescent cells contribute to …
SARS-CoV-2 and the DNA damage response
RJ Grand - Journal of General Virology, 2023 - microbiologyresearch.org
The recent coronavirus disease 2019 (COVID-19) pandemic was caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is characterized by …
respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is characterized by …
Nei-like DNA glycosylase 2 selectively antagonizes interferon-β expression upon respiratory syncytial virus infection
As part of the antiviral response, cells activate the expressions of type I interferons (IFNs)
and proinflammatory mediators to control viral spreading. Viral infections can impact DNA …
and proinflammatory mediators to control viral spreading. Viral infections can impact DNA …
Self-DNA driven inflammation in COVID-19 and after mRNA-based vaccination: lessons for non-COVID-19 pathologies
M Heil - Frontiers in Immunology, 2024 - frontiersin.org
The coronavirus disease 2019 (COVID-19) pandemic triggered an unprecedented
concentration of economic and research efforts to generate knowledge at unequalled speed …
concentration of economic and research efforts to generate knowledge at unequalled speed …
[HTML][HTML] Drug repurposing platform for deciphering the druggable SARS-CoV-2 interactome
Abstract The coronavirus disease 2019 (COVID-19) pandemic has heavily challenged the
global healthcare system. Despite the vaccination programs, the new virus variants are …
global healthcare system. Despite the vaccination programs, the new virus variants are …
Autophagy and SARS-CoV-2-old players in new games
T Ivanova, Y Mariienko, N Mehterov… - International Journal of …, 2023 - mdpi.com
At present it is well-defined that autophagy is a fundamental process essential for cell life but
its pro-viral and anti-viral role has been stated out with the COVID pandemic. However …
its pro-viral and anti-viral role has been stated out with the COVID pandemic. However …
[HTML][HTML] Age-related influence on DNA damage, proteomic inflammatory markers and oxidative stress in hospitalized COVID-19 patients compared to healthy controls
A Draxler, A Blaschke, J Binar, M Weber, M Haslacher… - Redox Biology, 2023 - Elsevier
COVID-19 infections are accompanied by adverse changes in inflammatory pathways that
are also partly influenced by increased oxidative stress and might result in elevated DNA …
are also partly influenced by increased oxidative stress and might result in elevated DNA …
Endothelial Glycocalyx Injury in SARS‐CoV‐2 Infection: Molecular Mechanisms and Potential Targeted Therapy
B Lv, S Huang, H Huang, N Niu… - Mediators of Inflammation, 2023 - Wiley Online Library
This review aims at summarizing state‐of‐the‐art knowledge on glycocalyx and SARS‐CoV‐
2. The endothelial glycocalyx is a dynamic grid overlying the surface of the endothelial cell …
2. The endothelial glycocalyx is a dynamic grid overlying the surface of the endothelial cell …