Age is the key risk factor for diseases and disabilities of the elderly. Efforts to tackle age-
related diseases and increase healthspan have suggested targeting the ageing process …

Biological age (BA) is important for clinical monitoring and preventing aging-related
disorders and disabilities. Clinical and/or cellular biomarkers are measured and integrated …

The diversity of cell types is a challenge for quantifying aging and its reversal. Here we
develop 'aging clocks' based on single-cell transcriptomics to characterize cell-type-specific …

Background Translating aging rejuvenation strategies into clinical practice has the potential
to address the unmet needs of the global aging population. However, to successfully do so …

Several age predictors based on DNA methylation, dubbed epigenetic clocks, have been
created in recent years, with the vast majority based on regularized linear regression. This …

Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …

Background Biological age is a measure of health that offers insights into ageing. The
existing age clocks, although valuable, often trade off accuracy and interpretability. We …

Aging is a complex and multifactorial process that increases the risk of various age-related
diseases and there are many aging clocks that can accurately predict chronological age …

XAI is a rapidly progressing field of machine learning, aiming to unravel the predictions of
complex models. XAI is especially required in sensitive applications, eg in health care, when …

Abstract Purpose of Review In the absence of a prophylactic/therapeutic vaccine or cure, the
most amazing achievement in the battle against HIV was the discovery of effective, well …