Mitochondria are the main source of reactive oxygen species (ROS) in cells. Early studies
have shown that mitochondrial reactive oxygen species (mROS) are related to the …

The transition between epithelial and mesenchymal phenotype is emerging as a key
determinant of tumor cell invasion and metastasis. It is a plastic process in which epithelial …

Skeletal muscle possesses a remarkable ability to adapt to various physiologic conditions.
AMPK is a sensor of intracellular energy status that maintains energy stores by fine-tuning …

Diet has a profound effect on tissue regeneration in diverse organisms, and low caloric
states such as intermittent fasting have beneficial effects on organismal health and age …

For nearly a century developmental biologists have recognized that cells from embryos can
differ in their potential to differentiate into distinct cell types. Recently, it has been recognized …

Reactive oxygen species (ROS) play an important role in determining the fate of normal
stem cells. Low levels of ROS are required for stem cells to maintain quiescence and self …

Due to their fundamental role in energy production, mitochondria have been traditionally
known as the powerhouse of the cell. Recent discoveries have suggested crucial roles of …

Mesenchymal stem cells (MSCs) are multipotent cells that show self-renewal, multi-
directional differentiation, and paracrine and immune regulation. As a result of these …

Metabolism has emerged as a key regulator of stem cell behavior. Mitochondria are crucial
metabolic organelles that are important for differentiated cells, yet considered less so for …

Pluripotent stem cells have distinct metabolic requirements, and reprogramming cells to
pluripotency requires a shift from oxidative to glycolytic metabolism. Here, we show that this …