Toll-like receptors (TLRs) are the most widespread class of membrane-bound innate
immune receptors, responsible of specific pathogen recognition and production of immune …

Finding the optimal balance between survival and reproduction is a central puzzle in life-
history theory. The terminal investment hypothesis predicts that when individuals encounter …

Abstract Sir Richard Peto is well known for proposing puzzling paradoxes in cancer biology—
some more well-known than others. In a 1984 piece, Peto proposed that after decades of …

Metabolic stress caused by excess nutrients accelerates aging. We recently demonstrated
that the newly discovered enzyme glycerol-3-phosphate phosphatase (G3PP; gene Pgp) …

Bats are exceptional among mammals for their powered flight, extended lifespans, and
robust immune systems and therefore have been of particular interest in comparative …

T cells are a type of white blood cell that play a critical role in the immune response against
foreign pathogens through a process called T cell adaptive immunity (TCAI). However, the …

Unveiling the genetic encodings of complex phenotypes is a fundamental goal of biology.
With the increasing availability of sequenced genomes, it has become possible to elucidate …