Aberrant glycans are a hallmark of cancer states. Notably, emerging evidence has
demonstrated that the diagnosis of cancers with tumour-specific glycan patterns holds great …

In the brain, astrocytes regulate shape and functions of the synaptic and vascular
compartments through a variety of released factors and membrane-bound proteins. An …

The molecular mechanisms connecting environmental exposures to adverse endpoints are
often unknown, reflecting knowledge gaps. At the Comparative Toxicogenomics Database …

Black men with prostate cancer have historically had worse outcomes than white men with
prostate cancer. The causes of this disparity in outcomes are multi-factorial, but a potential …

Humans exhibit considerable variability in their immune responses to the same immune
challenges. Such variation is widespread and affects individual and population‐level …

Beyond initial discovery of a pathogenic variant, establishing that a variant is recurrently
associated with disease is important for understanding clinical impact and disease etiology …

Genotype× environment interactions (GxE) have long been recognized as a key mechanism
underlying human phenotypic variation. Technological developments over the past 15 years …

This comprehensive review article delves into the critical role of the human microbiota in the
development and management of endocrine-related diseases. We explore the complex …

In this perspective we discuss the current lack of genetic and environmental diversity in
functional genomics datasets. There is a well-described Eurocentric bias in genetic and …

Gene–environment interactions (G× E), the interplay of genetic variation with environmental
factors, have a pivotal impact on human complex traits and diseases. Statistically, G× E can …