Lung cancer stands as the primary contributor to cancer-related fatalities worldwide,
affecting both genders. Two primary types exist where non-small cell lung cancer (NSCLC) …

Interconnected, fundamental aging processes are central to many illnesses and diseases.
Cellular senescence is a mechanism that halts the cell cycle in response to harmful stimuli …

Objectives Age is the strongest risk factor of giant cell arteritis (GCA), implying a possible
pathogenetic role of cellular senescence. To address this question, we applied an …

The currently available anti-cancer therapies, such as gamma-radiation and
chemotherapeutic agents, induce cell death and cellular senescence not only in cancer cells …

Giant cell arteritis (GCA) is an autoimmune disease affecting large vessels in patients over
50 years old. It is an exemplary model of a classic inflammatory disorder with IL-6 playing …

Estrogen receptor positive (ER+) breast cancer is the most common breast cancer
diagnosed annually in the US with endocrine-based therapy as standard-of-care for this …

Artificial intelligence (AI) platforms, such as Generative Pretrained Transformer (ChatGPT),
have achieved a high degree of popularity within the scientific community due to their utility …

Several breakthrough articles have recently confirmed the ability of tumor cells to escape the
stable cell cycle arrest imposed by Therapy-Induced Senescence (TIS). Subsequently …

Abstract The 2023 Annual Review Issue of The Journal of Pathology, Recent Advances in
Pathology, contains 12 invited reviews on topics of current interest in pathology. This year …

The DNA damage response (DDR) pathway is a cardinal cellular stress response
mechanism that during cancer development follows an antagonistic pleiotropy mode of …