Tools and strategies for analysis of genome-wide and gene-specific DNA methylation patterns
DNA methylation is a stable epigenetic mechanism that has important roles in the normal
function of a cell and therefore also in disease etiology. Accurate measurements of normal …
function of a cell and therefore also in disease etiology. Accurate measurements of normal …
[HTML][HTML] Prenatal exposure to phthalates and peripheral blood and buccal epithelial DNA methylation in infants: an epigenome-wide association study
Background Prenatal exposure to phthalates has been associated with adverse health and
neurodevelopmental outcomes. DNA methylation (DNAm) alterations may be a mechanism …
neurodevelopmental outcomes. DNA methylation (DNAm) alterations may be a mechanism …
[HTML][HTML] An epigenome-wide association study meta-analysis of educational attainment
The epigenome is associated with biological factors, such as disease status, and
environmental factors, such as smoking, alcohol consumption and body mass index …
environmental factors, such as smoking, alcohol consumption and body mass index …
[HTML][HTML] Prenatal fine particulate matter exposure, placental DNA methylation changes, and fetal growth
This study was designed to examine the impact of prenatal fine particulate matter (PM 2.5)
exposure on fetal growth and the underlying placental epigenetic mechanism in a cohort of …
exposure on fetal growth and the underlying placental epigenetic mechanism in a cohort of …
[HTML][HTML] Epigenetic regulation of placental gene expression in transcriptional subtypes of preeclampsia
Background Preeclampsia (PE) is a heterogeneous, hypertensive disorder of pregnancy,
with no robust biomarkers or effective treatments. We hypothesized that this heterogeneity is …
with no robust biomarkers or effective treatments. We hypothesized that this heterogeneity is …
[HTML][HTML] Genome-wide DNA methylation profiles indicate CD8+ T cell hypermethylation in multiple sclerosis
Objective Determine whether MS-specific DNA methylation profiles can be identified in
whole blood or purified immune cells from untreated MS patients. Methods Whole blood …
whole blood or purified immune cells from untreated MS patients. Methods Whole blood …
[HTML][HTML] DNA methylation signatures of monozygotic twins clinically discordant for multiple sclerosis
NY Souren, LA Gerdes, P Lutsik, G Gasparoni… - Nature …, 2019 - nature.com
Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous
system with a modest concordance rate in monozygotic twins, which strongly argues for …
system with a modest concordance rate in monozygotic twins, which strongly argues for …
Immunity drives TET1 regulation in cancer through NF-κB
E Collignon, A Canale, C Al Wardi, M Bizet… - Science …, 2018 - science.org
Ten-eleven translocation enzymes (TET1, TET2, and TET3), which induce DNA
demethylation and gene regulation by converting 5-methylcytosine (5mC) to 5 …
demethylation and gene regulation by converting 5-methylcytosine (5mC) to 5 …
[HTML][HTML] Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits
SB Zaghlool, B Kühnel, MA Elhadad, S Kader… - Nature …, 2020 - nature.com
DNA methylation and blood circulating proteins have been associated with many complex
disorders, but the underlying disease-causing mechanisms often remain unclear. Here, we …
disorders, but the underlying disease-causing mechanisms often remain unclear. Here, we …
[HTML][HTML] Meta-analysis of human methylomes reveals stably methylated sequences surrounding CpG islands associated with high gene expression
Background DNA methylation is thought to play an important role in the regulation of
mammalian gene expression, partly based on the observation that a lack of CpG island …
mammalian gene expression, partly based on the observation that a lack of CpG island …