Alzheimer's disease-related epigenetic changes: novel therapeutic targets

A Paniri, MM Hosseini, H Akhavan-Niaki - Molecular Neurobiology, 2024 - Springer
Aging is a significant risk factor for Alzheimer's disease (AD), although the precise
mechanism and molecular basis of AD are not yet fully understood. Epigenetic mechanisms …

The Role of Hydrogen Sulfide (H2S) in Epigenetic Regulation of Neurodegenerative Diseases: A Systematic Review

BG Dogaru, C Munteanu - International Journal of Molecular Sciences, 2023 - mdpi.com
This review explores the emerging role of hydrogen sulfide (H2S) in modulating epigenetic
mechanisms involved in neurodegenerative diseases. Accumulating evidence has begun to …

Triaging between post-translational modification of cell cycle regulators and their therapeutics in neurodegenerative diseases

N Rani, M Sahu, RK Ambasta, P Kumar - Ageing Research Reviews, 2023 - Elsevier
Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and
Huntington's disease, present challenges in healthcare because of their complicated …

G-quadruplexes and associated proteins in aging and Alzheimer's disease

MJ Vijay Kumar, R Morales, AS Tsvetkov - Frontiers in Aging, 2023 - frontiersin.org
Aging is a prominent risk factor for many neurodegenerative disorders, such as Alzheimer's
disease (AD). Alzheimer's disease is characterized by progressive cognitive decline …

Epidrugs in the therapy of central nervous system disorders: a way to drive on?

MG Gladkova, E Leidmaa, EA Anderzhanova - Cells, 2023 - mdpi.com
The polygenic nature of neurological and psychiatric syndromes and the significant impact
of environmental factors on the underlying developmental, homeostatic, and neuroplastic …

Insights into the Role of Histone Methylation in Brain Aging and Potential Therapeutic Interventions

N Vitorakis, C Piperi - International Journal of Molecular Sciences, 2023 - mdpi.com
Epigenetic mechanisms play a primary role in the cellular damage associated with brain
aging. Histone posttranslational modifications represent intrinsic molecular alterations …

Novel histone post-translational modifications in Alzheimer's disease: current advances and implications

Y Qin, P Yang, W He, D Li, L Zeng, J Li, T Zhou… - Clinical …, 2024 - Springer
Alzheimer's disease (AD) has a complex pathogenesis, and multiple studies have indicated
that histone post-translational modifications, especially acetylation, play a significant role in …

Neurotoxic effects induced by flunitrazepam and its metabolites in zebrafish: Oxidative stress, apoptosis, and histone hypoacetylation

Y Qin, Y Huang, W Lin, R Huang, K Li, X Han… - Science of The Total …, 2024 - Elsevier
Benzodiazepines (BZDs) have been widely detected in aquatic environments, but their
neurotoxic effects and potential mechanisms are still unclear. This study focuses on …

Differential Epigenetic Changes in the Dorsal Hippocampus of Male and Female SAMP8 Mice: A Preliminary Study

F Ravanelli, L Musazzi, SS Barbieri, G Rovati… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is the most common age-related neurodegenerative disease
characterized by memory loss and cognitive impairment. The causes of the disease are not …

A bibliometric and visual analysis of epigenetic research publications for Alzheimer's disease (2013–2023)

YP Zhao, WJ Ai, JF Zheng, XL Hu… - Frontiers in Aging …, 2024 - frontiersin.org
Background Currently, the prevalence of Alzheimer's disease (AD) is progressively rising,
particularly in developed nations. There is an escalating focus on the onset and progression …