Aging constitutes the main risk factor for the development of neurodegenerative diseases.
This represents a major health issue worldwide that is only expected to escalate due to the …

Increasing evidence has associated the exposure of endocrine-disrupting chemicals (EDCs)
with the cardiovascular (CV) system. This exposure is particularly problematic in a sensitive …

Epigenetic information is available from contemporary organisms, but is difficult to track back
in evolutionary time. Here, we show that genome-wide epigenetic information can be …

Lipofuscin is an intracellular aggregate of highly oxidized proteins that cannot be digested in
the ubiquitin-proteasome system and accumulate mainly in lysosomes, especially in aged …

Biological ageing and its mechanistic underpinnings are of immense biomedical and
ecological significance. Ageing involves the decline of diverse biological functions and …

Abstract Changes in DNA methylation at specific CpG sites have been used to build
predictive models to estimate animal age, predominantly in mammals. Little testing for this …

Aging is a complex process indicated by low energy levels, declined physiological activity,
stress induced loss of homeostasis leading to the risk of diseases and mortality. Recent …

Human ageing is a complex and integrated gradual deterioration of cellular processes.
There are nine major hallmarks of ageing, that include changes in DNA repair and DNA …

Senescence was originally identified by the finite lifespan of normal cells that is a
consequence of telomere shortening with each cycle of DNA replication. Cells undergoing …

Introduction: Hypermethylation of genes associated with promoter CpG islands, and
hypomethylation of CpG poor genes, repeat sequences, transposable elements and …