The aging–cancer cycle: mechanisms and opportunities for intervention

MS Sedrak, HJ Cohen - The Journals of Gerontology: Series A, 2023 - academic.oup.com
Aging is the largest risk factor for the development of cancer. A growing body of literature
indicates that aging and cancer often play a somewhat reciprocal relationship at various …

Cancer statistics in Pakistan from 1994 to 2021: data from cancer registry

M Tufail, C Wu - JCO Clinical Cancer Informatics, 2023 - ascopubs.org
PURPOSE Pakistan has been systematically collecting cancer data since 1994 through
cancer registries. METHODS This article presents a comprehensive analysis of cancer …

[HTML][HTML] Combination of the biomarkers for aging and cancer?-Challenges and current status

D Li, F Ju, H Wang, C Fan, JC Jacob, S Gul… - Translational …, 2023 - Elsevier
The proportion of patients diagnosed with cancer has been shown to rise with the increasing
aging global population. Advanced age is a major risk factor for morbidity and mortality in …

[HTML][HTML] The role of SOX transcription factors in ageing and age-related diseases

M Stevanovic, A Lazic, M Schwirtlich… - International Journal of …, 2023 - mdpi.com
The quest for eternal youth and immortality is as old as humankind. Ageing is an inevitable
physiological process accompanied by many functional declines that are driving factors for …

[HTML][HTML] A systematic review on the potential acceleration of neurocognitive aging in older cancer survivors

C Kerstens, HPMW Wildiers, G Schroyen, M Almela… - Cancers, 2023 - mdpi.com
Simple Summary As survival rates for cancer increase and most patients exceed the age of
65 years, more emphasis has gone to possible cognitive sequelae, which could be …

[HTML][HTML] Antibody and Cell-Based Therapies against Virus-Induced Cancers in the Context of HIV/AIDS

J Joseph, G Sandel, R Kulkarni, R Alatrash, BB Herrera… - Pathogens, 2023 - mdpi.com
Infectious agents, notably viruses, can cause or increase the risk of cancer occurrences.
These agents often disrupt normal cellular functions, promote uncontrolled proliferation and …

[HTML][HTML] Recent progress in bio-responsive drug delivery systems for tumor therapy

X Cong, J Chen, R Xu - Frontiers in Bioengineering and …, 2022 - frontiersin.org
Spatially-and/or temporally-controlled drug release has always been the pursuit of drug
delivery systems (DDSs) to achieve the ideal therapeutic effect. The abnormal …

[HTML][HTML] CO-induced TTP activation alleviates cellular senescence and age-dependent hepatic steatosis via downregulation of PAI-1

J Park, Y Chen, J Kim, E Hwang, GH Park… - Aging and …, 2023 - ncbi.nlm.nih.gov
Aging can increase the risk of various hepatic diseases, especially non-alcoholic fatty liver
disease (NAFLD). Although the mechanisms underlying the pathogenesis of age-related …

[HTML][HTML] Elevated level of nerve growth factor (NGF) in serum-derived exosomes predicts poor survival in patients with breast cancer undergoing neoadjuvant …

HH Jung, JY Kim, EY Cho, JM Oh, JE Lee, SW Kim… - Cancers, 2021 - mdpi.com
Simple Summary Exosomes and cytokines play crucial roles in the process of tumor
progression. Recent studies have reported that cytokines can be packaged into exosomes …

The aged tumor microenvironment limits T cell control of cancer

ACY Chen, S Jaiswal, D Martinez, C Yerinde, K Ji… - Nature …, 2024 - nature.com
The etiology and effect of age-related immune dysfunction in cancer is not completely
understood. Here we show that limited priming of CD8+ T cells in the aged tumor …