Evolutionary cancer cell biology reveals that the majority of cancer hallmarks trace their
origins back to the premetazoic era. These cancer stem cell hallmarks share deep homology …

Abstract Transformation-related protein 53 (Trp53) is a critical regulator of cell fate
determination by controlling cell proliferation and differentiation. Ablation of Trp53 signaling …

Senescent cells have been recognized to play major roles in tumor progression and are
nowadays included in the hallmarks of cancer. Our work aims to develop a mathematical …

Contexto: El incremento de la población de adultos mayores en Colombia se acompaña de
un aumento en la incidencia de cáncer, lo que plantea desafíos para la atención integral de …

Bats are remarkably long-lived for their size with many species living more than 20-40 years,
suggesting that they possess efficient anti-aging and anti-cancer defenses. Here we …

This work attempts to bring together knowledge of different pathways associated with
cellular ageing and create connections between them using both machine learning and …

Ovarian cancer, primarily diagnosed at advanced stages of the disease, is the most lethal of
all gynaecological malignancies, with a 5-year survival of only 45%. Increasing age and …

Ageing can be broadly described as a progressive decline in physiological functions,
leading to increased susceptibility to diseases and mortality. Ageing is the most important …

The article focuses on survival rates for most head and neck cancers that have seen large
statistically significant improvements. Topics include examines this is attributed in part to …

Pathological expression of the MYC oncogene is a common denominator in a wide range of
cancers and is linked with abnormal cell proliferation. To achieve this status, the MYC gene …