Stem cells are captivating because they have the potential to make multiple cell types yet
maintain their undifferentiated state. Recent studies of Drosophila and mammalian neural …

The mature, functional, and healthy eye is generated by the coordinated regulatory
interaction of numerous and diverse developing tissues. The neural retina of the eye must …

Müller glial cells ensheath all retinal neurons in vertebrate retinae. There are a multitude of
functional interactions between neurons and Müller cells, including delivery of the light …

Human induced pluripotent stem cells (hiPSCs) have been shown to differentiate along the
retinal lineage in a manner that mimics normal mammalian development. Under certain …

Traumatic brain injury (TBI) promotes neural stem/progenitor cell (NSC) proliferation in an
attempt to initiate innate repair mechanisms. However, all immature neurons in the CNS are …

In this study, we describe an in vivo RNA interference functional genetics approach to
evaluate the role of 20 different conserved polarity factors and fate determinants in mouse …

The retinas of teleost fish have long been of interest to developmental neurobiologists for
their persistent plasticity during growth, life history changes, and response to injury. Because …

Precise regulation of stem cell self-renewal/differentiation is essential for embryogenesis
and tumor suppression. Drosophila neural progenitors (neuroblasts) align their spindle …

The cellular effects of the genetic defects associated with tumorigenesis are context
dependent. To better understand the reasons that different cell types require distinct …

The retinoblastoma susceptibility gene (RB1) was the first tumor suppressor gene identified
in humans (Friend, et al., 1986) and the first tumor suppressor gene knocked out by targeted …