W Tu, S Rao - Frontiers in microbiology, 2016 - frontiersin.org
The ability of the human immune system to protect against infectious disease declines with age and efficacy of vaccination reduces significantly in the elderly. Aging of the immune …
CE Gustafson, C Kim, CM Weyand… - Journal of Allergy and …, 2020 - Elsevier
Impaired vaccine responses in older individuals are associated with alterations in both the quantity and quality of the T-cell compartment with age. As reviewed herein, the T-cell …
The topic of human longevity has invited extensive scientific and philosophic debate. Haller, a prominent Swiss physiologist of the 18th century, thought that people ought to live to 200 …
Memory stem T cells (TSCMs) constitute a long-lived, self-renewing lymphocyte population essential for the maintenance of functional immunity. Hallmarks of autoimmune disease …
E Grebenciucova, JR Berger - Current neurology and neuroscience …, 2017 - Springer
Abstract Purpose of Review This review highlights some of the important changes in the immune system that occur in the process of normal aging. Immunosenescence as a concept …
C Kim, RR Jadhav, CE Gustafson, MJ Smithey… - Cell reports, 2019 - cell.com
Generation of protective immunity to infections and vaccinations declines with age. Studies in healthy individuals have implicated reduced miR-181a expression in T cells as …
Aim The increased number of individuals older than 80 years, centenarians, and supercentenarians is not a synonym for healthy aging, since severe infections …
ME Rudolph, MA McArthur, RS Barnes… - Frontiers in …, 2018 - frontiersin.org
Toxic shock syndrome (TSS) is capable of inducing life-threatening fever, rash, and systemic organ failure, though the specific mechanisms behind these symptoms remain poorly …