Immunosenescence: a key player in cancer development

J Lian, Y Yue, W Yu, Y Zhang - Journal of hematology & oncology, 2020 - Springer
Immunosenescence is a process of immune dysfunction that occurs with age and includes
remodeling of lymphoid organs, leading to changes in the immune function of the elderly …

Mechanisms underlying T cell immunosenescence: aging and cytomegalovirus infection

W Tu, S Rao - Frontiers in microbiology, 2016 - frontiersin.org
The ability of the human immune system to protect against infectious disease declines with
age and efficacy of vaccination reduces significantly in the elderly. Aging of the immune …

Influence of immune aging on vaccine responses

CE Gustafson, C Kim, CM Weyand… - Journal of Allergy and …, 2020 - Elsevier
Impaired vaccine responses in older individuals are associated with alterations in both the
quantity and quality of the T-cell compartment with age. As reviewed herein, the T-cell …

Influence of aging and environment on presentation of infection in older adults

NG El Chakhtoura, RA Bonomo… - Infectious Disease …, 2017 - id.theclinics.com
The topic of human longevity has invited extensive scientific and philosophic debate. Haller,
a prominent Swiss physiologist of the 18th century, thought that people ought to live to 200 …

Memory stem T cells in autoimmune disease: high frequency of circulating CD8+ memory stem cells in acquired aplastic anemia

K Hosokawa, P Muranski, X Feng… - The Journal of …, 2016 - journals.aai.org
Memory stem T cells (TSCMs) constitute a long-lived, self-renewing lymphocyte population
essential for the maintenance of functional immunity. Hallmarks of autoimmune disease …

Immunosenescence: the role of aging in the predisposition to neuro-infectious complications arising from the treatment of multiple sclerosis

E Grebenciucova, JR Berger - Current neurology and neuroscience …, 2017 - Springer
Abstract Purpose of Review This review highlights some of the important changes in the
immune system that occur in the process of normal aging. Immunosenescence as a concept …

Проточная цитометрия в биомедицинских исследованиях

АВ Зурочка, СВ Хайдуков, ИВ Кудрявцев… - 2018 - elibrary.ru
В монографии изложены современные взгляды на применение проточной
цитофлуориметрии в норме и при различных патологических процессах. Приведена …

Defects in antiviral T cell responses inflicted by aging-associated miR-181a deficiency

C Kim, RR Jadhav, CE Gustafson, MJ Smithey… - Cell reports, 2019 - cell.com
Generation of protective immunity to infections and vaccinations declines with age. Studies
in healthy individuals have implicated reduced miR-181a expression in T cells as …

Parameters of the immune system and vitamin D levels in old individuals

AS Alves, ME Ishimura, YAO Duarte… - Frontiers in …, 2018 - frontiersin.org
Aim The increased number of individuals older than 80 years, centenarians, and
supercentenarians is not a synonym for healthy aging, since severe infections …

Differences Between Pediatric and Adult T Cell Responses to In Vitro Staphylococcal Enterotoxin B Stimulation

ME Rudolph, MA McArthur, RS Barnes… - Frontiers in …, 2018 - frontiersin.org
Toxic shock syndrome (TSS) is capable of inducing life-threatening fever, rash, and systemic
organ failure, though the specific mechanisms behind these symptoms remain poorly …