Frailty is a multiply determined, age-related state of increased risk for adverse health
outcomes. We review how the degree of frailty conditions the development of late-life …

As global life expectancy continues to rise, we are challenged with maintaining health into
old age. One strategy is to target the chronic low-level inflammation associated with aging …

Despite limited genomic diversity, severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) has shown a wide range of clinical manifestations in different patient populations …

Despite vaccine availability, influenza remains a substantial global public health concern.
Here, we report interim findings on the primary and secondary objectives of the safety …

Development of safe and effective COVID-19 vaccines is a global priority and the best hope
for ending the COVID-19 pandemic. Remarkably, in less than 1 year, vaccines have been …

Aging is a gradual, continuous series of natural changes in biological, physiological,
immunological, environmental, psychological, behavioral, and social processes. Aging …

We detected delayed and reduced antibody and T-cell responses after BNT162b2
vaccination in 71 elderly persons (median age 81 years) compared with 123 healthcare …

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Older adults are far more vulnerable to adverse health outcomes and mortality after
contracting COVID-19. There are likely multiple age-related biological, clinical, and …

There is a great deal of debate on the question of whether or not we know what ageing is
(Ref. Cohen et al., 2020). Here, we consider what we believe to be the especially confused …