The inflammaging concept was introduced in 2000 by Prof. Franceschi. This was an
evolutionary or rather a revolutionary conceptualization of the immune changes in response …

The immune system is the most important protective physiological system of the organism. It
has many connections with other systems and is, in fact, often considered as part of the …

These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …

Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections
and cancers in animal models and humans. Tex cells are characterized by progressive loss …

Aging is characterized by a morpho-functional adaptation, variably affecting major
physiological systems, depending on a complex interaction between genetic, environmental …

Background Aging is accompanied by alterations in immune response which leads to
increased susceptibility to infectious diseases, cancer, autoimmunity, and inflammatory …

Insufficient blood levels of the neurohormone vitamin D are associated with increased risk of
COVID-19 severity and mortality. Despite the global rollout of vaccinations and promising …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces a T cell
response that most likely contributes to virus control in COVID-19 patients but may also …

Aging leads to a progressive functional decline of the immune system, rendering the elderly
increasingly susceptible to disease and infection. The degree to which immune cell …

T cell senescence has been recognized to play an immunosuppressive role in the aging
population and cancer patients. Strategies dedicated to preventing or reversing replicative …