Are the healthy vulnerable? Cytomegalovirus seropositivity in healthy adults is associated with accelerated epigenetic age and immune dysregulation
Background Evaluating age as a risk factor for susceptibility to infectious diseases,
particularly coronavirus disease 2019 (COVID-19), is critical. Cytomegalovirus (CMV) …
particularly coronavirus disease 2019 (COVID-19), is critical. Cytomegalovirus (CMV) …
Pregnancy as a model for aging
The process of aging can be defined as the sum accumulation of damages and changes in
metabolism during the life of an organism, due to both genetic predisposition and stochastic …
metabolism during the life of an organism, due to both genetic predisposition and stochastic …
Early signs of gut microbiome aging: biomarkers of inflammation, metabolism, and macromolecular damage in young adulthood
Emerging links between gut microbiota and diseases of aging point to possible shared
immune, metabolic, and cellular damage mechanisms, operating long before diseases …
immune, metabolic, and cellular damage mechanisms, operating long before diseases …
Beyond monogenetic rare variants: tackling the low rate of genetic diagnoses in predominantly antibody deficiency
Predominantly antibody deficiency (PAD) is the most prevalent form of primary
immunodeficiency, and is characterized by broad clinical, immunological and genetic …
immunodeficiency, and is characterized by broad clinical, immunological and genetic …
[HTML][HTML] Current estimates of T cell kinetics in humans
Stable isotope labeling is a generally applicable method of quantifying cell dynamics. Its
advent has opened up the way for the quantitative study of T cells in humans. However, the …
advent has opened up the way for the quantitative study of T cells in humans. However, the …
Targeting impaired antimicrobial immunity in the brain for the treatment of Alzheimer's disease
T Fulop, S Tripathi, S Rodrigues… - Neuropsychiatric …, 2021 - Taylor & Francis
Alzheimer's disease (AD) is the most common form of dementia and aging is the most
common risk factor for developing the disease. The etiology of AD is not known but AD may …
common risk factor for developing the disease. The etiology of AD is not known but AD may …
Age-associated CD4+ T cells with B cell–promoting functions are regulated by ZEB2 in autoimmunity
M Goto, H Takahashi, R Yoshida, T Itamiya… - Science …, 2024 - science.org
Aging is a significant risk factor for autoimmunity, and many autoimmune diseases tend to
onset during adulthood. We conducted an extensive analysis of CD4+ T cell subsets from …
onset during adulthood. We conducted an extensive analysis of CD4+ T cell subsets from …
Toxoplasma gondii IgG Serointensity Is Positively Associated With Frailty
H Mohyuddin, B Laffon, JP Teixeira… - The Journals of …, 2024 - academic.oup.com
Background Persistent inflammation related to aging (“inflammaging”) is exacerbated by
chronic infections and contributes to frailty in older adults. We hypothesized associations …
chronic infections and contributes to frailty in older adults. We hypothesized associations …
Peripheral immunophenotype in dementia with Lewy bodies and Alzheimer's disease: an observational clinical study
Background Inflammation plays a key role in the aetiology and progression of Alzheimer's
disease (AD). However, the immunophenotype of the second most common …
disease (AD). However, the immunophenotype of the second most common …
[HTML][HTML] A long way to the battlefront: CAR T cell therapy against solid cancers
Z Wang, W Chen, X Zhang, Z Cai, W Huang - Journal of Cancer, 2019 - ncbi.nlm.nih.gov
Chimeric antigen receptors (CARs) are engineered synthetic receptors that redirect and
reprogram T cells to tumor surface antigens for subsequent eradication. The unprecedented …
reprogram T cells to tumor surface antigens for subsequent eradication. The unprecedented …