Degenerative diseases affecting bone tissues and the brain represent important problems
with high socio-economic impact. Certain bone diseases, such as osteoporosis, are …

The misfolding and aggregation of α-synuclein is the general hallmark of a group of
devastating neurodegenerative pathologies referred to as synucleinopathies, such as …

Aims Age and sex are important individual factors modifying the clinical symptoms of
patients with Parkinson's disease (PD). Our goal is to evaluate the effects of age and sex on …

Although neuromelanin is a dark pigment characteristic of dopaminergic neurons in the
human substantia nigra pars compacta, its potential role in the pathogenesis of Parkinson's …

Parkinson's disease (PD) is a neurodegenerative disease. Repetitive transcranial magnetic
stimulation (rTMS) is a therapeutic tool in PD. High-throughput sequencing was performed to …

Background Parkinson's disease (PD) is a motor disorder characterized by the degeneration
of dopaminergic neurons, putatively due to the accumulation of α-synuclein (α-syn) in Lewy …

Parkinson's disease (PD) pathophysiology includes mitochondrial dysfunction,
neuroinflammation, and aging as its biggest risk factors. Mitochondrial DNA copy number …

The gut-brain axis plays an important role in Parkinson's disease (PD) by acting as a route
for vagal propagation of aggregated α-synuclein in the gut-first endophenotype and as a …

Introduction A key pathological event occurring in Parkinson's disease (PD) is the
transneuronal spreading of alpha-synuclein (α-syn). Other hallmarks of PD include …

Parkinson's disease (PD) is an incurable and progressive neurological disorder leading to
deleterious motor and non-motor consequences. Presently, no pharmacological agents can …