Multi‐omics usually refers to the crossover application of multiple high‐throughput screening
technologies represented by genomics, transcriptomics, single‐cell transcriptomics …

Both obesity and aging are associated with the development of metabolic diseases such as
type 2 diabetes and cardiovascular disease. Chronic low-grade inflammation of adipose …

Gene expression profiling has identified numerous processes altered in aging, but how
these changes arise is largely unknown. Here we combined nascent RNA sequencing and …

Endurance exercise is a widely accessible, low-cost intervention with a variety of benefits to
multiple organ systems. Exercise improves multiple indices of physical performance and …

Aging is a dynamic, time-dependent process that is characterized by a gradual accumulation
of cell damage. Continual functional decline in the intrinsic ability of living organisms to …

During aging, body adiposity increases with changes in the metabolism of lipids and their
metabolite levels. Considering lipid metabolism, excess adiposity with increased lipotoxicity …

Aging can be seen as a physiological progression of biomolecular damage and the
accumulation of defective cellular components, which trigger and amplify the process …

We previously identified 529 proteins that had been reported by multiple different studies to
change their expression level with age in human plasma. In the present study, we measured …

The development of clinical interventions that significantly improve human healthspan
requires robust markers of biological age as well as thoughtful therapeutic targets. To …

Being characterized by progressive and severe damage in neuronal cells,
neurodegenerative diseases (NDDs) are the major cause of disability and morbidity in the …