Ageing is associated with modified function of both innate and adaptive immunity. It is
believed that changes occurring in ageing immune system are responsible for increased …

The function of the immune system declines during aging, compromising its response
against pathogens, a phenomenon termed as “immunosenescence.” Alterations of the …

The magnitude and quality of the germinal center (GC) response decline with age, resulting
in poor vaccine-induced immunity in older individuals. A functional GC requires the co …

There is a dramatic remodeling of the T cell compartment during aging. The most notorious
changes are the reduction of the naive T cell pool and the accumulation of memory-like T …

The failure to generate enduring humoral immunity after vaccination is a hallmark of
advancing age. This can be attributed to a reduction in the germinal center (GC) response …

In the last century, we have seen a dramatic rise in the number of older persons globally, a
trend known as the grey (or silver) tsunami. People live markedly longer than their …

Emerging and re-emerging viral diseases have increased in number and geographical
extent during the last decades. Examples include the current COVID-19 pandemic and the …

To date there has been limited head-to-head evaluation of immune responses to different
types of COVID-19 vaccines. A real-world population-based longitudinal study was …

Vaccination is an excellent strategy to limit the morbidity and mortality associated with
infectious disease. Vaccination creates protective, long-lived antibody-mediated immunity by …

Since its emergence in late 2019, the coronavirus disease 2019 (COVID‐19) pandemic has
caused substantial morbidity and mortality. Despite the availability of efficacious vaccines …