We present a systematic analysis of epigenetic age acceleration based on by far the largest
collection of publicly available DNA methylation data for healthy samples (93 datasets, 23 K …

Humanized mouse models can be used to explore human gene regulatory elements (REs),
which frequently lie in non-coding and less conserved genomic regions. Epigenetic …

Background Early life adversity and psychiatric disorders are associated with earlier
declines in neurocognitive abilities during adulthood. These declines may be preceded by …

The debate surrounding nature versus nurture remains a central question in neuroscience,
psychology, and in psychiatry, holding implications for both aging processes and the …

Background Schizophrenia is associated with increased risk of developing multiple aging-
related diseases, including metabolic, respiratory, and cardiovascular diseases, and …

The aim of this study was to evaluate the associations between psychological resilience and
epigenetic clocks assessed by DNA methylation age predictions. We used data from 4018 …

Background Childhood maltreatment and psychiatric morbidity have each been associated
with accelerated biological aging primarily through cross-sectional studies. Using data from …

Health problems associated with aging are a major public health concern for the future.
Aging is a complex process with wide intervariability among individuals. Therefore, there is a …

The existence of a shared genetic basis for mental disorders has long been documented, yet
research on whether acquired epigenetic modifications exhibit common alterations across …

This study is the first systematic meta-analysis of epigenetic age acceleration of the largest
publicly available DNA methylation data for healthy samples (93 datasets, 23K samples) …