It has been noted for quite some time that DNA methylation levels decline with age. The
significance of this change remained unknown until it became possible to measure …

The genomic hypomethylation hypothesis of aging proposes that an overall decrease in
global DNA methylation occurs with age, and it has been argued that the decrease in global …

Background Mammalian species exhibit a wide range of lifespans. To date, a robust and
dynamic molecular readout of these lifespan differences has not yet been identified. Recent …

Recently, there has been an increase in the incidence of malignant tumors among the older
population. Moreover, there is an association between aging and cancer. During the …

Biological age, distinct from an individual's chronological age, has been studied extensively
through predictive aging clocks. However, these clocks have limited accuracy in short time …

Human DNA methylation profiles have been used successfully to develop highly accurate
biomarkers of aging (“epigenetic clocks”). Although these human epigenetic clocks are not …

BACKGROUND Rising maternal ages and age-related fertility decline are a global
challenge for modern reproductive medicine. Clinicians and researchers pay specific …

Background & Aims The epithelia of the intestine and colon turn over rapidly and are
maintained by adult stem cells at the base of crypts. Although the small intestine and colon …

A critical hallmark of aging is cellular senescence, a state of growth arrest and inflammatory
cytokine release in cells, caused by a variety of stresses. Recent work has convincingly …

Growth hormone (GH) actions impact growth, metabolism, and body composition and have
been associated with aging and longevity. Lack of GH results in slower growth, delayed …