Diet and depression: exploring the biological mechanisms of action
The field of nutritional psychiatry has generated observational and efficacy data supporting a
role for healthy dietary patterns in depression onset and symptom management. To guide …
role for healthy dietary patterns in depression onset and symptom management. To guide …
Human age reversal: Fact or fiction?
AA Johnson, BW English, MN Shokhirev… - Aging …, 2022 - Wiley Online Library
Although chronological age correlates with various age‐related diseases and conditions, it
does not adequately reflect an individual's functional capacity, well‐being, or mortality risk …
does not adequately reflect an individual's functional capacity, well‐being, or mortality risk …
Neurobiology of bipolar disorders: a review of genetic components, signaling pathways, biochemical changes, and neuroimaging findings
Bipolar disorder (BD) is a chronic mental illness characterized by changes in mood that
alternate between mania and hypomania or between depression and mixed states, often …
alternate between mania and hypomania or between depression and mixed states, often …
Mitochondria DNA copy number, mitochondria DNA total somatic deletions, Complex I activity, synapse number, and synaptic mitochondria number are altered in …
Mitochondrial dysfunction is a neurobiological phenomenon implicated in the
pathophysiology of schizophrenia and bipolar disorder that can synergistically affect …
pathophysiology of schizophrenia and bipolar disorder that can synergistically affect …
Brain age in mood and psychotic disorders: a systematic review and meta‐analysis
PL Ballester, MT Romano… - Acta Psychiatrica …, 2022 - Wiley Online Library
Objective To evaluate whether accelerated brain aging occurs in individuals with mood or
psychotic disorders. Methods A systematic review following PRISMA guidelines was …
psychotic disorders. Methods A systematic review following PRISMA guidelines was …
Accelerated aging in bipolar disorder: A comprehensive review of molecular findings and their clinical implications
GR Fries, MJ Zamzow, T Andrews, O Pink… - Neuroscience & …, 2020 - Elsevier
Bipolar disorder (BD) has been associated with clinical signs of accelerated aging, which
potentially underlies its association with several age-related medical conditions, such as …
potentially underlies its association with several age-related medical conditions, such as …
Comprehensive summary of mitochondrial DNA alterations in the postmortem human brain: A systematic review
Summary Background Mitochondrial DNA (mtDNA) encodes 37 genes necessary for
synthesizing 13 essential subunits of the oxidative phosphorylation system. mtDNA …
synthesizing 13 essential subunits of the oxidative phosphorylation system. mtDNA …
Telomere length and mitochondrial DNA copy number in bipolar disorder: identification of a subgroup of young individuals with accelerated cellular aging
Abstract The 10–15-years decrease in life expectancy observed in individuals with bipolar
disorder (BD) has been linked to the concept of accelerated cellular aging. Telomere length …
disorder (BD) has been linked to the concept of accelerated cellular aging. Telomere length …
Mitochondrial dysfunction as a critical event in the pathophysiology of bipolar disorder
G Scaini, T Andrews, CNC Lima, D Benevenuto… - Mitochondrion, 2021 - Elsevier
The understanding of the pathophysiology of bipolar disorder (BD) remains modest, despite
recent advances in neurobiological research. The mitochondrial dysfunction hypothesis of …
recent advances in neurobiological research. The mitochondrial dysfunction hypothesis of …
Decreased DNA methylation at promoters and gene-specific neuronal hypermethylation in the prefrontal cortex of patients with bipolar disorder
Bipolar disorder (BD) is a severe mental disorder characterized by repeated mood swings.
Although genetic factors are collectively associated with the etiology of BD, the underlying …
Although genetic factors are collectively associated with the etiology of BD, the underlying …