Caloric restriction, intermittent fasting, and exercise activate defensive cellular responses
such as autophagy, DNA repair, and the induction of antioxidant enzymes. These processes …

Age-related macular degeneration (AMD) is the major cause of blindness in developed
nations. AMD is characterized by retinal pigmented epithelial (RPE) cell dysfunction and …

Sustained mitochondrial fitness relies on coordinated biogenesis and clearance. Both
processes are regulated by constant targeting of proteins into the organelle. Thus …

Evidence supports the notion that metabolic pathways are major regulators of organismal
aging, and that metabolic perturbations can extend health-and lifespan. For this reason …

Salmonella enterica serovar Typhimurium (S. Typhimurium) is a Gram-negative pathogen
that causes various host-specific diseases. During their life cycle, Salmonellae survive …

Human health requires homeostasis and coherence to respond to stress and synchronize
physiological functions. This state of balance is gradually lost during aging when senescent …

Progressive reduction in kidney function in patients following myocardial infarction (MI) is
associated with an increase in circulating uremic toxins levels leading to increased …

Cardiovascular disease, including cardiac hypertrophy, is common in patients with kidney
disease and can be partially attenuated using blockers of the renin-angiotensin system …

More and more evidence has showed that low glycaemic index (GI) diet was a benefit to the
Type 2 Diabetes Mellitus (T2DM). However, the detailed mechanism was not clear. Here, we …

The TGFβ family member myostatin (growth/differentiation factor-8) is a negative regulator of
skeletal muscle growth. The hypermuscular Compact mice carry the 12-bp Mstn (Cmpt …