Every cell must satisfy basic requirements for nutrient sensing, utilization and recycling
through macromolecular breakdown to coordinate programmes for growth, repair and stress …

The protonation state of soluble and membrane-associated macromolecules dictates their
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …

Lysosomal acidification dysfunction has been implicated as a key driving factor in the
pathogenesis of neurodegenerative diseases, including Alzheimer's disease and …

Lysosomes critically rely on bis (monoacylglycero) phosphate (BMP) to stimulate lipid
catabolism, cholesterol homeostasis, and lysosomal function. Alterations in BMP levels in …

In response to lysosomal damage, cells engage several quality-control mechanisms,
including the selective isolation and degradation of damaged lysosomes by lysophagy …

The discovery of effective drugs for the treatment of neurodegenerative disorders (NDs) is a
deadlock. Due to their complex etiology and high heterogeneity, progresses in the …

Targeted degradation of the cell-surface and extracellular proteins via the endogenous
lysosomal degradation pathways, such as lysosome-targeting chimeras (LYTACs), has …

Disturbances of lipid homeostasis in cells provoke human diseases. The elucidation of the
underlying mechanisms and the development of efficient therapies represent formidable …

BODIPY and its derivative multifunctional small molecule probes have become the darlings
in the field of biomedical materials due to its unique molecular structure, high brightness …

The incidence of tissue and organ damage caused by various diseases is increasing
worldwide. Tissue engineering is a promising strategy of tackling this problem because of its …