Several biomarkers of healthy aging have been proposed in recent years, including the
epigenetic clocks, based on DNA methylation (DNAm) measures, which are getting …

Background There has been a steady increase in the number of studies aiming to identify
DNA methylation differences associated with complex phenotypes. Many of the challenges …

Background Epigenetic clocks can track both chronological age (cAge) and biological age
(bAge). The latter is typically defined by physiological biomarkers and risk of adverse health …

Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by the
progressive accumulation of amyloid-beta and neurofibrillary tangles of tau in the neocortex …

Epigenetic dysregulation may influence disease progression. Here we explore whether
epigenetic alterations in human pancreatic islets impact insulin secretion and type 2 …

Assisted reproductive technology (ART) may affect fetal development through epigenetic
mechanisms as the timing of ART procedures coincides with the extensive epigenetic …

Epigenetic processes, including DNA methylation (DNAm), are among the mechanisms
allowing integration of genetic and environmental factors to shape cellular function. While …

Skeletal muscle tissue demonstrates global hypermethylation with age. However,
methylome changes across the time-course of differentiation in aged human muscle derived …

Background: Epigenetic dysregulation has been proposed as a key mechanism for arsenic-
related cardiovascular disease (CVD). We evaluated differentially methylated positions …

As the master regulator in utero, the placenta is core to the Developmental Origins of Health
and Disease (DOHaD) hypothesis but is historically understudied. To identify placental gene …