[HTML][HTML] Biomarkers of aging in frailty and age-associated disorders: State of the art and future perspective

S Salvioli, MS Basile, L Bencivenga, S Carrino… - Ageing Research …, 2023 - Elsevier
According to the Geroscience concept that organismal aging and age-associated diseases
share the same basic molecular mechanisms, the identification of biomarkers of age that can …

[HTML][HTML] Epigenetic reprogramming as a key to reverse ageing and increase longevity

B Pereira, FP Correia, IA Alves, M Costa… - Ageing research …, 2024 - Elsevier
The pursuit for the fountain of youth has long been a fascination amongst scientists and
humanity. Ageing is broadly characterized by a cellular decline with increased susceptibility …

Genetic evidence for causal effects of socioeconomic, lifestyle, and cardiometabolic factors on epigenetic-age acceleration

L Kong, C Ye, Y Wang, T Hou, J Zheng… - The Journals of …, 2023 - academic.oup.com
Abstract GrimAge acceleration (GrimAgeAccel) and PhenoAge acceleration
(PhenoAgeAccel) are DNA methylation-based markers of accelerated biological aging …

[HTML][HTML] Metal mixtures and DNA methylation measures of biological aging in American Indian populations

K Boyer, A Domingo-Relloso, E Jiang, K Haack… - Environment …, 2023 - Elsevier
Abstract Introduction Native American communities suffer disproportionately from elevated
metal exposures and increased risk for cardiovascular diseases and diabetes. DNA …

[HTML][HTML] The mixed effect of Endocrine-Disrupting chemicals on biological age Acceleration: Unveiling the mechanism and potential intervention target

W Huang, Z Zhang, M Colucci, L Deng, M Yang… - Environment …, 2024 - Elsevier
Introduction Although previous studies investigated the potential adverse effects of
endocrine-disrupting chemicals (EDCs) on biological age acceleration and aging-related …

[HTML][HTML] A unified model of age-related cardiovascular disease

M Fossel, J Bean, N Khera, MG Kolonin - Biology, 2022 - mdpi.com
Simple Summary Age-related cardiovascular disease is the foremost cause of death
globally. Despite medical advances, we have been unable to stop or reverse the underlying …

[HTML][HTML] Yearning for machine learning: applications for the classification and characterisation of senescence

BK Hughes, R Wallis, CL Bishop - Cell and Tissue Research, 2023 - Springer
Senescence is a widely appreciated tumour suppressive mechanism, which acts as a barrier
to cancer development by arresting cell cycle progression in response to harmful stimuli …

[HTML][HTML] Forensic age estimation through a DNA methylation-based Age Prediction Model in the Italian Population: a pilot study

M Onofri, A Delicati, B Marcante, L Carlini… - International Journal of …, 2023 - mdpi.com
DNA methylation is one of the epigenetic marks which has been studied intensively in recent
years for age predicting purposes in the forensic area. In order to integrate age prediction …

[HTML][HTML] Different aspects of aging in migraine

M Fila, E Pawlowska, J Szczepanska… - Aging and Disease, 2023 - ncbi.nlm.nih.gov
Migraine is a common neurological disease displaying an unusual dependence on age. For
most patients, the peak intensity of migraine headaches occurs in 20s and lasts until 40s, but …

DNA methylation as a window into female reproductive aging

AK Knight, JB Spencer, AK Smith - Epigenomics, 2024 - Taylor & Francis
People with ovaries experience reproductive aging as their reproductive function and
system declines. This has significant implications for both fertility and long-term health, with …