Hindbrain adrenergic/noradrenergic nuclei facilitate endocrine and autonomic responses to
physical and psychological challenges. Neurons that synthesize adrenaline and …

Mood and anxiety disorders are complex heterogeneous syndromes that manifest in
dysfunctions across multiple brain regions, cell types, and circuits. Biomarkers using brain …

Psychological stress confers an increased risk for several diseases including psychiatric
conditions. The susceptibility to psychological stress is modulated by various factors, many …

Introduction Obesity and psychosocial stress (PS) co-exist in individuals of Western society.
Nevertheless, how PS impacts cardiac and hippocampal phenotype in obese subjects is still …

Prior research suggests that the neurobiological underpinnings of depression include
aberrant brain functional connectivity, neurometabolite levels, and hippocampal volume …

Both the ostensibly aversive effects of unpredictable episodes of social stress and the
intensely rewarding effects of drugs of abuse activate the mesocorticolimbic dopamine …

Rationale Exposure to social defeat (SD) induces a depressive phenotype, increased
ethanol seeking and consumption, accompanied by activation of the neuroinflammatory …

Anxiety disorders often manifest in genetically susceptible individuals after psychosocial
stress, but the mechanisms underlying these gene-environment interactions are largely …

Altered activity of corticolimbic brain regions is a hallmark of stress-related illnesses,
including mood disorders, neurodegenerative diseases, and substance abuse disorders …

Stressful life events are major environmental risk factors for anxiety disorders, although not
all individuals exposed to stress develop clinical anxiety. The molecular mechanisms …