Ethnopharmacological relevance Depression is a major mental disorder and it is currently
recognized as the second-leading cause of disability worldwide. However, the therapeutic …

Mood disorders are recurrent/chronic diseases with variable clinical remission rates.
Available antidepressants are not effective in all patients and often show a relevant …

This study aimed to evaluate research findings on the role of polyunsaturated fatty acids
(PUFAs) in neuronal signaling. Polyunsaturated fatty acids (PUFAs) are the building blocks …

Depression is a serious neuropsychiatric disease affecting an increasing number of people
worldwide. Cognitive deficits (including inattention, poor memory, and decision-making …

The serotonin transporter (SERT) tightly regulates synaptic serotonin levels and has been
the primary target of antidepressants. Binding of inhibitors to the allosteric site of human …

Physical activity (PA) is an effective way of increasing cognitive and emotional health and
counteracting many psychiatric conditions. Numerous neurobiological models for …

Context Crocin exhibits anti-depressant properties. However, its underlying mechanisms
and its relationship with metabolomics remain unclear. Objective This study elucidates the …

Persistent stress increases the probability for developing depression significantly thereafter.
Repeated social defeat stress is a widely used model to investigate depressive-like behavior …

The compound N-(3-(phenylselanyl) prop-2-yn-1-yl) benzamide (SePB), which combines a
selenium atom and a benzamide nucleus in an organic structure, has demonstrated a fast …

According to reports by the World Health Organization, neuropsychiatric disorders,
particularly anxiety and depression, are the leading cause of disability around the world …