Phospholipids with two polyunsaturated fatty acyl tails promote ferroptosis

B Qiu, F Zandkarimi, CT Bezjian, E Reznik, RK Soni… - Cell, 2024 - cell.com
Phospholipids containing a single polyunsaturated fatty acyl tail (PL-PUFA 1 s) are
considered the driving force behind ferroptosis, whereas phospholipids with diacyl-PUFA …

Lipid and glucose metabolism in senescence

B Liu, Q Meng, X Gao, H Sun, Z Xu, Y Wang… - Frontiers in …, 2023 - frontiersin.org
Senescence is an inevitable biological process. Disturbances in glucose and lipid
metabolism are essential features of cellular senescence. Given the important roles of these …

A Putative Role of Candida albicans in Promoting Cancer Development: A Current State of Evidence and Proposed Mechanisms

J Talapko, T Meštrović, B Dmitrović, M Juzbašić… - Microorganisms, 2023 - mdpi.com
Candida albicans is a commensal fungal species that commonly colonizes the human body,
but it is also a pervasive opportunistic pathogen in patients with malignant diseases. A …

[HTML][HTML] Beyond the adverse effects of the systemic route: exploiting nanocarriers for the topical treatment of skin cancers

B da Silva Gomes, AC Paiva-Santos, F Veiga… - Advanced Drug Delivery …, 2024 - Elsevier
Skin cancer is a heterogeneous disease that can be divided into two main groups,
melanoma and nonmelanoma skin cancers. Conventional therapies for skin cancer have …

[HTML][HTML] 2, 8-Dihydroxyadenine-induced nephropathy causes hexosylceramide accumulation with increased mTOR signaling, reduced levels of protective SirT3 …

J Moellmann, K Krueger, DWL Wong… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Aim Chronic kidney disease (CKD) is accompanied by increased cardiovascular risk and
heart failure (HF). In rodents, 2, 8-dihydroxyadenine (DHA)-induced nephropathy is a …

Analysis of triacylglycerol and phospholipid sn‐positional isomers by liquid chromatographic and mass spectrometric methodologies

M Fabritius, B Yang - Mass Spectrometry Reviews, 2023 - Wiley Online Library
Abstract Analysis of triacylglycerol (TG) and phospholipid sn‐positional isomers can be
divided into two main categories:(a) direct separation by chromatography or other means …

Phosphatidylethanolamine N-Methyltransferase Knockout Modulates Metabolic Changes in Aging Mice

Q Zhou, F Zhang, J Kerbl-Knapp, M Korbelius… - Biomolecules, 2022 - mdpi.com
Phospholipid metabolism, including phosphatidylcholine (PC) biosynthesis, is crucial for
various biological functions and is associated with longevity. Phosphatidylethanolamine N …

Omics analysis unveils changes in the metabolome and lipidome of Caenorhabditis elegans upon polydopamine exposure

BT Nguyen, QV Le, J Ahn, KA Nguyen… - … of Pharmaceutical and …, 2024 - Elsevier
Polydopamine (PDA) is an insoluble biopolymer with a dark brown-black color that forms
through the autoxidation of dopamine. Because of its outstanding biocompatibility and …

Metabolic impact of polyphenol-rich aronia fruit juice mediated by inflammation status of gut microbiome donors in humanized mouse model

SMG Wilson, JT Peach, H Fausset, ZT Miller… - Frontiers in …, 2023 - frontiersin.org
Background The Aronia melanocarpa fruit is emerging as a health food owing to its high
polyphenolic content and associated antioxidant activity. Antioxidant-rich foods, such as …

Isolation, identification, and degradation mechanism by multi-omics of mesotrione-degrading Amycolatopsis nivea La24

Q Li, Q Ma, Y Zhou, X Jiang, RE Parales, S Zhao… - Journal of Hazardous …, 2024 - Elsevier
Mesotrione is a herbicide used in agricultural production; however, its stability and long-term
residues pose ecological risks to soil health and subsequent crops. In this research, the …