Ageing is characterized by the progressive loss of cellular homeostasis, leading to an
overall decline of the organism's fitness. In the brain, ageing is highly associated with …

With a graying population and increasing longevity, it is essential to identify life transition in
later years and discern heterogeneity among older people. Subclassifying the elderly …

Age-related and chemotherapy-induced bone loss depends on cellular senescence and the
cell secretory phenotype. However, the factors secreted in the senescent microenvironment …

With increasing human life expectancy, the global medical burden of chronic diseases is
growing. Hence, chronic diseases are a pressing health concern and will continue to be in …

Background: As the largest organ in the human body, the skin is continuously exposed to
intrinsic and extrinsic stimuli that impact its functionality and morphology with aging. Skin …

The hematopoietic stem cell (HSC) niche is a specialized microenvironment, where a
complex and dynamic network of interactions across multiple cell types regulates HSC …

Highlights•Specialized plasma cells (PCs) reside in multiple tissues throughout the body.•A
clonally related network of Immunoglobulin (Ig) A PCs occurs at mucosal sites.•Bone marrow …

Stroke is a devastating cause of global morbidity and mortality. Ischemic brain injury triggers
a profound local and systemic immune response that participates in stroke pathophysiology …

Gene expression alterations occurring with aging have been described for a multitude of
species, organs, and cell types. However, most of the underlying studies rely on static …

A vast body of studies is available that describe age-dependent gene expression in relation
to aging in a number of different model species. These data were obtained from animals …