[HTML][HTML] Deep phenotyping and lifetime trajectories reveal limited effects of longevity regulators on the aging process in C57BL/6J mice
Current concepts regarding the biology of aging are primarily based on studies aimed at
identifying factors regulating lifespan. However, lifespan as a sole proxy measure for aging …
identifying factors regulating lifespan. However, lifespan as a sole proxy measure for aging …
Age and sex: impact on adipose tissue metabolism and inflammation
Age associated chronic inflammation is a major contributor to diseases with advancing age.
Adipose tissue function is at the nexus of processes contributing to age-related metabolic …
Adipose tissue function is at the nexus of processes contributing to age-related metabolic …
Multiregion transcriptomic profiling of the primate brain reveals signatures of aging and the social environment
Aging is accompanied by a host of social and biological changes that correlate with
behavior, cognitive health and susceptibility to neurodegenerative disease. To understand …
behavior, cognitive health and susceptibility to neurodegenerative disease. To understand …
Ageing induces tissue‐specific transcriptomic changes in Caenorhabditis elegans
Ageing is a complex process with common and distinct features across tissues. Unveiling
the underlying processes driving ageing in individual tissues is indispensable to decipher …
the underlying processes driving ageing in individual tissues is indispensable to decipher …
[HTML][HTML] The'middle-aging'brain
Middle age has historically been an understudied period of life compared to older age, when
cognitive and brain health decline are most pronounced, but the scope for intervention may …
cognitive and brain health decline are most pronounced, but the scope for intervention may …
Concordance of MERFISH spatial transcriptomics with bulk and single-cell RNA sequencing
Spatial transcriptomics extends single-cell RNA sequencing (scRNA-seq) by providing
spatial context for cell type identification and analysis. Imaging-based spatial technologies …
spatial context for cell type identification and analysis. Imaging-based spatial technologies …
Aging is associated with increased chromatin accessibility and reduced polymerase pausing in liver
M Bozukova, C Nikopoulou… - Molecular Systems …, 2022 - embopress.org
Regulation of gene expression is linked to the organization of the genome. With age,
chromatin alterations occur on all levels of genome organization, accompanied by changes …
chromatin alterations occur on all levels of genome organization, accompanied by changes …
Interactions between mitochondrial dysfunction and other hallmarks of aging: Paving a path toward interventions that promote healthy old age
Current research on human aging has largely been guided by the milestone paper
“hallmarks of aging,” which were first proposed in the seminal 2013 paper by Lopez‐Otin et …
“hallmarks of aging,” which were first proposed in the seminal 2013 paper by Lopez‐Otin et …
[HTML][HTML] Network-level analysis of ageing and its relationship with diseases and tissue regeneration in the mouse liver
M Porukala, PK Vinod - Scientific Reports, 2023 - nature.com
The liver plays a vital role in maintaining whole-body metabolic homeostasis, compound
detoxification and has the unique ability to regenerate itself post-injury. Ageing leads to …
detoxification and has the unique ability to regenerate itself post-injury. Ageing leads to …
Limited proteolysis–mass spectrometry reveals aging-associated changes in cerebrospinal fluid protein abundances and structures
Cerebrospinal fluid (CSF) proteins and their structures have been implicated in aging and
neurodegenerative diseases. In the present study, we used limited proteolysis–mass …
neurodegenerative diseases. In the present study, we used limited proteolysis–mass …