During aging, the loss of metabolic homeostasis drives a myriad of pathologies. A central
regulator of cellular energy, the AMP-activated protein kinase (AMPK), orchestrates …

The progressive decline of physiological function and the increased risk of age-related
diseases challenge healthy aging. Multiple anti-aging manipulations, such as senolytics …

Aging promotes chronic inflammation, which contributes to fibrosis and decreases organ
function. Fibrosis, the excessive synthesis and deposition of extracellular matrix …

The human aging process is associated with molecular changes and cellular degeneration,
resulting in a significant increase in cancer incidence with age. Despite their potential …

Objective Pancreatic β cells play a key role in maintaining glucose homeostasis; dysfunction
of this critical cell type causes type 2 diabetes (T2D). Emerging evidence points to sex …

Aging is often associated with a loss of cell type identity that results in an increase in
transcriptional noise in aged tissues. If this phenomenon reflects a fundamental property of …

Aging in humans is an incredibly complex biological process that leads to increased
susceptibility to various diseases. Understanding which genes are associated with healthy …

Investigation of the molecular mechanisms of aging in the human heart is challenging
because of confounding factors, such as diet and medications, as well as limited access to …

Background As a result of aging, skeletal muscle undergoes atrophy and a decrease in
function. This age-related skeletal muscle weakness is known as “sarcopenia”. Sarcopenia …

Non-canonical lipolysis induced by inflammatory cytokines or Toll-like receptor ligands is
required for the regulation of inflammation during endotoxemia and sepsis. Canonical …