Organs and tissues age at different rates within a single individual. Such asynchrony in
aging has been widely observed at multiple levels, from functional hallmarks, such as …

Common characteristics of aging include reduced somatic stem cell number, susceptibility to
cardiac injuries, metabolic imbalances and increased risk for oncogenesis. In this study …

Adipose tissue undergoes significant anatomical and functional changes with aging, leading
to an increased risk of metabolic diseases. Age-related changes in adipose tissue include …

Aging is characterized by chronic low‐grade inflammation in multiple tissues, also termed
“inflammaging”, which represents a significant risk factor for many aging‐related chronic …

Dietary restriction (DR) is a universal anti-aging intervention, which reduces age-related
nervous system pathologies and neurological decline. The degree to which the …

Regenerative medicine, poised to transform 21st century healthcare, has aspired to enrich
care options by bringing cures to patients in need. Science-driven responsible and …

Introduction Even during physiologic aging, the kidney experiences a loss of mass and a
progressive functional decline. This is clinically relevant as it leads to an increased risk of …

The elderly males undergo degenerative fertility and testicular endocrine function that
jeopardize the reproductive health and well-being. However, the mechanisms underlying …

Metabolism plays an important role in regulating aging at several levels, and metabolic
reprogramming is the main driving force of aging. Due to the different metabolic needs of …

Kidney tubules use fatty acid oxidation (FAO) to support their high energetic requirements.
Carnitine palmitoyltransferase 1A (CPT1A) is the rate-limiting enzyme for FAO, and it is …