Several metabolic alterations accumulate over time along with a reduction in biological
fitness, suggesting the existence of a" metabolic clock" that controls aging. Multiple inborn …

The aging process is driven by interrelated mechanisms that lead to the emergence of
characteristic phenotypes that include changes in body composition, energy production and …

Neuronal development in the human cerebral cortex is considerably prolonged compared
with that of other mammals. We explored whether mitochondria influence the species …

How metabolism is reprogrammed during neuronal differentiation is unknown. We found that
the loss of hexokinase (HK2) and lactate dehydrogenase (LDHA) expression, together with …

The anti-diabetic drug metformin targets pancreatic cancer stem cells (CSCs), but not their
differentiated progenies (non-CSCs), which may be related to distinct metabolic phenotypes …

Lactate has long been considered a “waste” by-product of cell metabolism, and it
accumulates at sites of inflammation. Recent findings have identified lactate as an active …

During eukaryotic evolution, ribosomes have considerably increased in size, forming a
surface-exposed ribosomal RNA (rRNA) shell of unknown function, which may create an …

A distinctive feature of stem cells is their capacity to self-renew to maintain pluripotency.
Studies of genetically-engineered mouse models and recent advances in metabolomic …

The field of regenerative medicine holds considerable promise for treating diseases that are
currently intractable. Although many researchers are adopting the strategy of cell …

Stem cells undergo a shift in metabolic substrate utilization during specification and/or
differentiation, a process that has been termed metabolic reprogramming. Here, we report …