Previous studies have shown that nitric oxide (NO) supplements may prevent bone loss and
fractures in preclinical models of estrogen deficiency. However, the mechanisms by which …

Mitochondria are considered highly plastic organelles. This plasticity enables the
mitochondria to undergo morphological and functional changes in response to cellular …

Insulin-like growth factor 1 (IGF-1) is an unique peptide that functions in an
endocrine/paracrine and autocrine manner in most tissues. Although it was postulated …

Stem cells and the niche in which they reside feature a complex microenvironment with
tightly regulated homeostasis, cell-cell interactions and dynamic regulation of metabolism. A …

Obesity is associated with increased risk for fragility fractures. However, the cellular
mechanisms are unknown. Using a translational approach combining RNA sequencing and …

How metabolism is rewired during embryonic development is still largely unknown, as it
remains a major technical challenge to resolve metabolic activities or metabolite levels with …

The routine application of human pluripotent stem cells (hPSCs) and their derivatives in
biomedicine and drug discovery will require the constant supply of high-quality cells by …

Investigations on developmental and regenerative myogenesis have led to major advances
in decrypting stem cell properties and potential, as well as their interactions within the …

Adipocytes are the main cell type in adipose tissue, which is a critical regulator of
metabolism, highly specialized in storing energy as fat. Adipocytes differentiate from …

Cells of unicellular and multicellular eukaryotes can respond to certain environmental cues
by arresting the cell cycle and entering a reversible state of quiescence. Quiescent cells do …