Multi-tissue DNA methylation age: molecular relationships and perspectives for advancing biomarker utility

JC Nwanaji-Enwerem, MG Weisskopf… - Ageing research …, 2018 - Elsevier
The multi-tissue DNA methylation estimator of chronological age (DNAm-age) has been
associated with a wide range of exposures and health outcomes. Still, it is unclear how …

A cost‐effective blood DNA methylation‐based age estimation method in domestic cats, Tsushima leopard cats (Prionailurus bengalensis euptilurus) and Panthera …

H Qi, QL Lim, K Kinoshita, N Nakajima… - Molecular Ecology …, 2024 - Wiley Online Library
Individual age can be used to design more efficient and suitable management plans in both
in situ and ex situ conservation programmes for targeted wildlife species. DNA methylation is …

How does evolutionary evaluation illuminate body size among canids?

BP Tangredi, DF Lawler - American Journal of Veterinary …, 2024 - Am Vet Med Assoc
In this review, we examine mammalian body size as it reflects life history and genomic
composition, with a primary focus on canids and the domestication of the gray wolf. The …

Age estimation of captive Asian elephants (Elephas maximus) based on DNA methylation: An exploratory analysis using methylation-sensitive high-resolution melting …

K Arai, H Qi, M Inoue-Murayama - Plos one, 2023 - journals.plos.org
Age is an important parameter for bettering the understanding of biodemographic trends—
development, survival, reproduction and environmental effects—critical for conservation …

Association of DNA methylation with energy and fear-related behaviors in canines

AR Sanders, N Bhongir, B vonHoldt… - Frontiers in …, 2022 - frontiersin.org
Introduction Behavioral traits are influenced by gene by environment interactions. To study
the genetic and epigenetic components of behavior, we analyzed whether dog behavioral …

IMAGE: high-powered detection of genetic effects on DNA methylation using integrated methylation QTL mapping and allele-specific analysis

Y Fan, TP Vilgalys, S Sun, Q Peng, J Tung, X Zhou - Genome biology, 2019 - Springer
Identifying genetic variants that are associated with methylation variation—an analysis
commonly referred to as methylation quantitative trait locus (mQTL) mapping—is important …

Epigenetic age estimation of wild mice using faecal samples

E Hanski, S Joseph, A Raulo, KM Wanelik… - Molecular …, 2024 - Wiley Online Library
Age is a key parameter in population ecology, with a myriad of biological processes
changing with age as organisms develop in early life then later senesce. As age is often …

Elixir of life: thwarting aging with regenerative reprogramming

E Beyret, P Martinez Redondo… - Circulation …, 2018 - Am Heart Assoc
All living beings undergo systemic physiological decline after ontogeny, characterized as
aging. Modern medicine has increased the life expectancy, yet this has created an aged …

Methylation‐based markers for the estimation of age in African cheetah, Acinonyx jubatus

LS Le Clercq, A Kotzé, JP Grobler… - Molecular Ecology …, 2024 - Wiley Online Library
Age is a key demographic in conservation where age classes show differences in important
population metrics such as morbidity and mortality. Several traits, including reproductive …

Insights into the molecular basis of genome stability and pristine proteostasis in naked mole-rats

V Narayan, M McMahon, JJ O'Brien… - … Extraordinary Biology of …, 2021 - Springer
The naked mole-rat (Heterocephalus glaber) is the longest-lived rodent, with a maximal
reported lifespan of 37 years. In addition to its long lifespan–which is much greater than …