[HTML][HTML] Sex-biased regulatory changes in the placenta of native highlanders contribute to adaptive fetal development
T Yue, Y Guo, X Qi, W Zheng, H Zhang, B Wang, K Liu… - eLife, 2024 - elifesciences.org
Compared with lowlander migrants, native Tibetans have a higher reproductive success at
high altitude though the underlying mechanism remains unclear. Here, we compared the …
high altitude though the underlying mechanism remains unclear. Here, we compared the …
Human genetics: An extreme fitness landscape
I Mathieson - Current Biology, 2023 - cell.com
Human genetics: An extreme fitness landscape Page 1 protein VasH is repressed, it cannot
positively regulate the T6SS and therefore T6SS is downregulated. Previously, the LitR protein …
positively regulate the T6SS and therefore T6SS is downregulated. Previously, the LitR protein …
Convergent genetic adaptation in human tumors developed under systemic hypoxia and in populations living at high altitudes
C Arenillas, J Ruiz-Cantador, L Celada, B Calsina… - bioRxiv, 2024 - biorxiv.org
EPAS1HIF2a is the primary gene implicated in systemic hypoxia adaptation. Conversely,
aberrantly activated EPAS1HIF2a acts as a tumor driver against which anti-tumor …
aberrantly activated EPAS1HIF2a acts as a tumor driver against which anti-tumor …
[HTML][HTML] DATA in BRIEF of: Adaptative Mechanisms indicated by Placental Protein Expression Changes in High-Altitude Tibetan Women during Vaginal delivery
H Liu, T Wuren, R Ge - Data in Brief, 2024 - Elsevier
Over a period of 30,000 to 40,000 years, high-altitude Tibetans have physiologically and
genetically adapted to conditions such as hypoxia, low temperature, and high-intensity …
genetically adapted to conditions such as hypoxia, low temperature, and high-intensity …
Detection of Domestication Signals through the Analysis of the Full Distribution of Fitness Effects using Simulations
D Castellano, IT Vourlaki, RN Gutenkunst… - bioRxiv, 2022 - biorxiv.org
The process of domestication involves a complex interplay between concurrent
demographic and selective changes. While we can readily observe the phenotypic effects of …
demographic and selective changes. While we can readily observe the phenotypic effects of …
[引用][C] Sex-biased adaptation shapes uniparental gene pools in Tibetans
MS Peng, YP Zhang - Science China Life Sciences, 2024 - Springer
During the past two decades, a series of archaeological and genetic investigations
substantially improve our perception of the hominin settlement of the Tibetan Plateau (Zhang …
substantially improve our perception of the hominin settlement of the Tibetan Plateau (Zhang …